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San Francisco 49ers schedule and 2021 season predictions

 4 days ago

San Francisco 49ers schedule this week

San Francisco 49ers are on a bye this week

San Francisco 49ers schedule predictions, roster outlook
May 25, 2021; Santa Clara, CA, USA; San Francisco 49ers quarterbacks Trey Lance (5) and Jimmy Garoppolo (10) throw the football during Organized Team Activities at San Francisco 49ers Training Facility. Mandatory Credit: Stan Szeto-USA TODAY Sports
  • The 49ers take on the Detroit Lions in Week 1 of the 2021 NFL season and boast the largest point spread right now.
  • With an early Week 6 bye, San Francisco will be forced to play 12 consecutive weeks to close out the regular season.
  • Sportsnaut predicts that the 49ers will finish with an 11-6 record.

Find out where the San Francisco 49ers stand in our most-recent NFL power rankings

San Francisco 49ers roster outlook

All of our predictions are based on the 49ers keeping and starting these key players:

  • QB — Jimmy Garoppolo , Trey Lance
  • RB — Elijah Mitchell, JaMycal Hasty (injured) Trey Sermon, Jeff Wilson (injured), Kerryon Johnson
  • FB — Kyle Juszczyk
  • TE — George Kittle, Ross Dwelley, Charlie Woerner
  • WR — Deebo Samuel, Trent Sherfield, Brandon Aiyuk, Mohamed Sanu, Jalen Hurd, Jauan Jennings
  • Defense — 49ers ranked 9th in the NFL this week

Week 1 — San Francisco 49ers defeated the Detroit Lions 41-33 on the road

  • When: Sunday, Sept. 12 at 1:00 PM on Fox
  • Spread: 49ers -7.5
  • Moneyline: Lions +300; 49ers -400
  • Sportsnaut prediction: 49ers 34, Lions 13

San Francisco was up 38-10 in the third quarter of Sunday’s game against the Detroit Lions, only to see the heavy home underdogs pull to within 41-33 with a chance to tie the game. While the 49ers’ defense held, this was not the way to end Week 1. The good news? Jimmy Garoppolo completed 17-of-25 passes for 314 yards in the win. Trey Lance also threw his first NFL touchdown.

Week 2 — San Francisco 49ers defeated the Philadelphia Eagles on the road, 17-11

  • When: Sunday, September 19 at 1:00 PM EST
  • Spread: 49ers -3.0
  • Moneyline: Eagles +130, 49ers -155
  • Over/under: 49.5
  • Sportsnaut prediction: 49ers 31, Eagles 20

A win is a win is a win. San Francisco heads home at 2-0 for just the second time in the past decade after a hard-fought victory over the Eagles in Philadelphia. That included taking a 17-3 lead late in the fourth quarter before having to sweat it out. Jimmy Garoppolo played another mistake-free game, completing 22-of-30 passes with two total touchdowns. Nick Bosa got to Jalen Hurts for two sacks.

Week 3 — San Francisco 49ers lose at home to the Green Bay Packers, 30-28

  • When: Sunday, September 26 at 8:20 PM EST on NBC
  • Spread: 49ers 3.0
  • Moneyline: Packers +145; 49ers -165
  • Over/under: 50.5
  • Sportsnaut prediction: 49ers 31, Packers 27

San Francisco could not do anything right for the first 29-plus minutes of Sunday night’s game against Green Bay. That’s until Trey Lance scored a touchdown at the end of the second quarter. Jimmy Garoppolo then led the 49ers on what should have been a game-winning drive that resulted in a touchdown with 37 seconds left. Unfortunately, San Francisco left Aaron Rodgers too much time — leading to a tough 30-28 home loss to Green Bay.

Week 4 — San Francisco 49ers lose to Seattle Seahawks, 28-21

  • When: Sunday, October 3 at 4:05 PM EST
  • Point spread: 49ers -2.5
  • Moneyline: Seahawks +115; 49ers -135
  • Over/under: 52.0
  • Sportsnaut prediction: 49ers 24, Seahawks 20 Also Read:
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That’s not what the 49ers wanted to see happen one week after a late-game loss to the Green Bay Packers. Jimmy Garoppolo went down before half with a calf injury after struggling big time. Continued mistakes in all three phases of the game led to a double-digit second-half deficit with rookie quarterback Trey Lance replacing Garoppolo under center. The question now becomes whether Lance is the better option moving forward after he put up 198 total yards and two touchdowns in the second half.

Week 5 — San Francisco 49ers lose to Arizona Cardinals, 17-10

  • When: Sunday, October 10 at 4:25 PM EST
  • Point spread: Cardinals -5.5
  • Moneyline: 49ers +190; Cardinals -230
  • Over/under: 48.5
  • Sportsnaut prediction: Cardinals 31, 49ers 27

Trey Lance did what he needed to do in the rookie’s starting debut. Unfortunately, some questionable coaching from Kyle Shanahan and dumb penalties on the 49ers’ offensive line led to a narrow 17-10 road loss heading into the bye. We’ll have to see what San Francisco has planned at quarterback moving forward now that it has lost three consecutive. If Jimmy Garoppolo is healthy, he’ll likely get the start Week 7.

San Francisco 49ers schedule predictions


Week 7 — vs. Indianapolis Colts (SNF)

Date Time (ET) TV
Sunday, Oct. 24 8:20 PM NBC

Whether the San Francisco 49ers start Trey Lance or Jimmy Garoppolo , this figures to be a low-scoring game. Both teams want to win with their defense and controlling the clock. Long drives, plenty of field goals and Carson Wentz making just enough plays in the final minutes to secure a victory.

  • Week 7 prediction: Colts 23, 49ers 17

Week 8 — @ Chicago Bears

Date Time (ET) TV
Sunday, Oct. 31 1:00 PM FOX

Perhaps, this could be a matchup between Trey Lance and Justin Fields . However, it now seems more likely that Chicago will roll with Andy Dalton under center. If so, Matt Nagy’s squad is much too limited on offense to really make this a competitive game. Expect a 49ers win going away in the Windy City.

  • Week 8 prediction: 49ers 31, Bears 20

Week 9 — vs. Arizona Cardinals

Date Time (ET) TV
Sunday, Nov. 7 4:25 PM FOX

Protecting the home field against fellow NFC West opponents is going to be a big deal for the 49ers in the ultra-competitive division. San Francisco is just 4-8 against said opponents at Levi’s Stadium since Kyle Shanahan took over in 2017. We’re expecting the team to flip the script in 2021. In this particular matchup, the 49ers’ defensive line will have a distinct advantage over the Arizona offensive line in front of Kyler Murray and be able to lead to a season split.

  • Week 9 prediction: 49ers 28, Cardinals 24

Week 10 — vs. Los Angeles Rams (MNF)

Date Time TV
Monday, Nov. 15 8:15 PM ESPN

Two of the favorites in the NFC West heading into the 2021 NFL season, whoever comes out on top in this division will have to take care of business in their head-to-head matchups. Unfortunately for the 49ers, Los Angeles seemingly has matchup advantages clear across the board. That includes Cooper Kupp and Robert Woods taking advantage of slower-footed 49ers cornerbacks and the presence of Aaron Donald against a still-questionable interior of the 49ers’ offensive line.

  • Week 10 prediction: Rams 31, 49ers 27

Week 11 — @ Jacksonville Jaguars

Date Time (ET) TV
Sunday, Nov. 21 1:00 PM FOX

Another potential matchup between two rookies, Trevor Lawrence is the sure-fire starter for Jacksonville. He also has a ton of weapons and a solid offensive line in front of him. At the very least, that should make Jacksonville competitive against better teams after losing its final 15 games a season ago. Unfortunately, the defense remains a major question-mark. Whether it’s Jimmy Garoppolo or Trey Lance under center for the 49ers, they should score enough to win in Duval.

Are the San Francisco 49ers legit Super Bowl contenders?

  • Week 11 prediction: 49ers 34, Jaguars 23
Logan Bowles/NFL Handout photo via USA TODAY Network

Week 12 — vs. Minnesota Vikings

Date Time (ET) TV
Sunday, Nov. 28 4:25 PM FOX

I am still not sold on Kirk Cousins being able to go to into Levi’s Stadium against a fully-healthy 49ers defense and accomplishing a darn thing. His last appearance against this unit led to an historically bad Vikings performance on offense. With Nick Bosa back and questions lingering on the Vikings’ offensive line, look for a narrow San Francisco home win.

  • Week 12 prediction: 49ers 24, Vikings 17

Week 13 — @ Seattle Seahawks (SNF)

Date Time (ET) TV
Sunday, Dec. 5 8:20 PM NBC

The recent history of this rivalry is interesting. Last season saw the 49ers lose by a mere three points in Seattle despite Garoppolo going down to an injury. Back in 2019, it clinched the NFC West with a dramatic win over the Seahawks in the Pacific Northwest in Week 17. What does this mean? Despite holes for both the Hawks and 49ers heading into 2021, we can expect close games. Look for Russell Wilson and Co. to hold court at home.

  • Week 13 prediction: Seahawks 31, 49ers 23

Week 14 — @ Cincinnati Bengals

Date Time (ET) TV
Sunday, Dec. 12 1:00 PM CBS

At the very least, Cincinnati should be fun in 2021. Last year’s No. 1 pick, Joe Burrow , is slated to return completely healthy after suffering a torn ACL in 2020. He’ll have rookie No. 5 pick Ja’Marr Chase to toss the rock to. Add in Tee Higgins, and this offense could be good. Unfortunately, the Bengals’ defensive front seven is a hot mess after their defense yielded nearly four touchdowns per game in 2020. The 49ers will take advantage of this.

  • Week 14 prediction: 49ers 34, Bengals 20
Sam Greene/Cincinnati Enquirer-USA TODAY NETWORK

Week 15 — vs. Atlanta Falcons

Date Time (ET) TV
Sunday, Dec. 19 1:00 PM CBS

The Kyle Shanahan game. Could this be Atlanta’s way of finally proving it has moved on from that era of Falcons football? I am not buying it in this Week 15 matchup in California. Whether it’s Jimmy Garoppolo or Trey Lance under center, these 49ers have way too much firepower on offense for the Falcons to be able to stay afloat.

  • Week 15 prediction: 49ers 35, Falcons 17

Week 16 — @ Tennessee Titans (TNF)

Date Time (ET) TV
Thursday, Dec. 23 8:20 PM NFL Network

Here’s an interesting stat. Ryan Tannehill is 18-8 as the Titans’ starter since joining the team back in 2019. Since the start of the 2014 season, all other Titans quarterbacks boast a combined 34-52 record as starters. There’s just something about Tannehill sharing a backfield with Derrick Henry. In and of itself, that should be enough for Tennessee to come out on top at home in what will be a hotly-contested affair. Add in the presence of Julio Jones against a now-questionable 49ers cornerback group, and it will lead to a Titans win.

  • Week 16 prediction: Titans 24, 49ers 21

Week 17 — vs. Houston Texans

Date Time (ET) TV
Sunday, Jan. 2 1:05 PM CBS

This could get laughably bad, especially if the 49ers are playing for postseason positioning and the Texans end up being as bad as we envision. Now that there’s a good chance Deshaun Watson could be forced to sit out the 2021 season, that’s magnified further. In fact, I wouldn’t be surprised if the 49ers ended up resting some of their starters after the first half in this home outing.

  • Week 17 prediction: 49ers 42, Texans 10

Week 18 — @ Los Angeles Rams

Date Time (ET) TV
Sunday, Jan. 9 4:25 PM FOX

Los Angeles won both games against its division rivals a season ago by a combined 11 points. That’s despite the fact Jared Goff threw two touchdowns against three interceptions in those matchups. With Matthew Stafford acting as a major upgrade under center in 2021, this won’t be a problem. At the very least, it should allow the Rams to protect their home-field in this matchup.

  • Week 18 prediction: Rams 28, 49ers 24

San Francisco 49ers projected record: 11-6

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