“She is literally driving Uber, doing other delivery services, and working at Walgreens to help pay off this debt so she can get her second surgery to get her tumor removed.”

There is a girl here in Alexandria, Virginia named Amana that I know through Young Bengali Professionals, a Bengali youth organization based in the DMV area. She was born with hemiphyperplasia, which means that she has extra cell growth on one side of her body. She now has a tumor growing on her flank area and is in the most awful situation. She is in so much debt from the first surgery and the only doctor who would take on her case in the DMV area is a plastic surgeon, and because of that her surgery is being considered “elective” and despite working with social workers and showing immense evidence, she is not eligible for charity care. (If you go on her gofundme page, you can see that she posted a screenshot of the costs of second surgery that the plastic surgeon has quoted her) She also makes too much for Medicaid and other insurance companies are still managing to discriminate against her for her preexisting condition, (even if it is against the law to do so.) or she can’t find a plan she can afford. And she’s went as far as Richmond to try to find other doctors who will take on her case, but no one is willing to due to the complexity of her case and her uninsured status.
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'I am grateful for all of you': 3News' Monica Robins announces she will again undergo surgery to remove brain tumor

CLEVELAND — On a special edition of her "Health Yeah!" podcast, our friend Monica Robins wanted to share an update with you regarding her own health. You may remember Monica was diagnosed with a brain tumor two years ago, later having surgery to remove most of it. Doctors were forced to leave some of it in due to concerns over Monica's safety.
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Woman's Shrinking Tumor Has Doctors Asking If CBD Oil Is Responsible

A new case study has suggested that cannabidiol (CBD) as an alternative cancer therapy may warrant further research, after an 80-year-old smoker’s lung tumor shrank despite declining medical treatment. The patient had been self-administering CBD oil several times daily for a period of 2.5 years, during which time a cancerous tumor in her lung shrank to a quarter of its original size. While it can’t be concluded that this patient’s improvement was down to CBD oil use, the authors say it’s possible a connection exists, warranting further research into the effects, if any, of CBD oil on cancerous tumors.
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Shrinking lung cancer tumor prompts call for more research on CBD

A unique lung cancer case has prompted a call for additional research into the popular cannabinoid CBD as a potential cancer treatment, according to a newly published report in BMJ Case Reports. Though more research is needed, CBD has grown in popularity as a medicinal compound, with user reports claiming effects like reduced inflammation, a decrease in pain, improvements in … Continue reading

Cancer cells mobilizing the nervous system? Let's use them to inhibit the tumor

Researchers at the Technion—Israel Institute of Technology have developed an innovative treatment for breast cancer, based on analgesic nanoparticles that target the nervous system. The study, published in Science Advances, was led by Professor Avi Schroeder and Ph.D. student Maya Kaduri of the Wolfson Faculty of Chemical Engineering. Breast cancer...

Using computer modeling to predict patient tumor responses to radiation therapy

Radiation treatment is one of the most frequently used therapies against cancer. However, despite its long and wide-ranging use, radiation therapy tends to be more of a one size fits all treatment with little regard to the biology of an individual patient's tumor. Researchers at Moffitt Cancer Center are trying to improve the personalization of radiation therapy through computer modeling. In a new study published in the journal Neoplasia, they model how interactions between cancer cells and immune cells, and their subsequent responses to radiation, impact the tumor. They propose their model may help to predict how patients respond to radiation therapy.

Modern Approaches to Treating Neuroendocrine Tumors

Eileen M. O’Reilly, MD, discusses the current treatment landscape for neuroendocrine tumors. Eileen M. O’Reilly, MD, Winthrop Rockefeller Endowed chair in Medical Oncology, co-director, Medical Initiatives, David M. Rubenstein Center for Pancreatic Cancer Research, and section head, Hepatopancreaticobilary & Neuroendocrine Cancers at Memorial Sloan Kettering Cancer Center, discusses the current treatment landscape for neuroendocrine tumors.

The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum

Pregnancy-associated malaria (PAM) threatened more than one million women and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and infant death1,2. VAR2CSA encoded by a subfamily of var genes from Plasmodium falciparum (P. falciparum) named as var2csa, plays a vital role in the cytoadherence of infected erythrocytes to the placenta3. Chondroitin sulfate A (CSA), which is displayed mostly on the surface of placental or tumor cells, has been recognized as a specific ligand for VAR2CSA4,5,6,7. However, the molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA remains elusive.

Sintilimab Meets Primary End Point in ORIENT-31 Trial for EGFR+ Non-Squamous NSCLC

Sintilimab with or without a bevacizumab biosimilar injection, combined with chemotherapy yielded promising findings in a population of patients with EGFR-mutant nonsquamous non–small cell lung cancer who have previously been treated with an EGFR tyrosine kinase inhibitor. Sintilimab (Tyvyt) has yielded a promising improvement to progression-free survival (PFS) in patients...

'The Future is Promising' For The Treatment of a Subtype of Non-Hodgkin Lymphoma

More selective BTK inhibitors like Brukinsa may give patients with mantle cell lymphoma who progressed on prior therapies another option with potentially fewer and more manageable side effects. Bruton tyrosine kinase (BTK) inhibitors have been a major focus of research for the treatment of patients with relapsed/refractory mantle cell lymphoma...

Researchers use game theory to understand how cells compete in tumors

Game theory applied to cell encounters inside a tumor provides a sociological perspective on the possible behaviors of cells in a collectivity, and offers a more comprehensive understanding of the complex rules that govern a neoplasm. In the first step of a study that is still in progress, it has been surmised that metastasis occurs in response to tumor heterogeneity.

Ochsner Hero: Dwight Warren

Most would describe Dwight or D.J., as everyone calls him, as quiet, humble, kind and always willing to help. In April of 2020 at the age of 17, D.J. was suddenly diagnosed with a brain tumor. He underwent brain surgery to remove most of the tumor, but also had to undergo chemotherapy treatment and physical therapy treatment to recover from his surgery. With determination, Faith in God, and support of family, friends, and Ochsner medical team D.J. Surprised everyone with a speedy recovery. He's stronger every day. DJ enjoys sports, spending time with his family, his favorite cousin and going to church on Sundays with his grandmother.

K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors

NKIRAS1 and NKIRAS2 (also called as κB-Ras) were identified as members of the atypical RAS family that suppress the transcription factor NF-κB. However, their function in carcinogenesis is still controversial. To clarify how NKIRAS acts on cellular transformation, we generated transgenic mice in which NKIRAS2 was forcibly expressed using a cytokeratin 15 (K15) promoter, which is mainly activated in follicle bulge cells. The ectopic expression of NKIRAS2 was mainly detected in follicle bulges of transgenic mice with NKIRAS2 but not in wild type mice. K15 promoter-driven expression of NKIRAS2 failed to affect the development of epidermis, which was evaluated using the expression of K10, K14, K15 and filaggrin. However, K15 promoter-driven expression of NKIRAS2 effectively suppressed the development of skin tumors induced by treatment with 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA). This observation suggested that NKIRAS seemed to function as a tumor suppressor in follicle bulges. However, in the case of oncogenic HRAS-driven cellular transformation of murine fibroblasts, knockdown of NKIRAS2 expression drastically suppressed HRAS-mutant-provoked cellular transformation, suggesting that NKIRAS2 was required for the cellular transformation of murine fibroblasts. Furthermore, moderate enforced expression of NKIRAS2 augmented oncogenic HRAS-provoked cellular transformation, whereas an excess NKIRAS2 expression converted its functional role into a tumor suppressive phenotype, suggesting that NKIRAS seemed to exhibit a biphasic bell-shaped enhancing effect on HRAS-mutant-provoked oncogenic activity. Taken together, the functional role of NKIRAS in carcinogenesis is most likely determined by not only cellular context but also its expression level.

Biomarker May Help Improve Mortality Risk Prediction in PAH

Endostatin could help measure pulmonary arterial hypertension (PAH) severity. Incorporating endostatin, a circulating angiostatic peptide, into commonly used risk prediction strategies for pulmonary arterial hypertension (PAH) improves prediction of mortality and thus serves as a robust, easily accessible biomarker of PAH severity, according to study findings published in ERJ Open Research.

Uveal Melanoma More Common in Men, Higher-latitude Locations

Those living in North Germany were found to have a lower rate of uveal melanoma compared to those in South Germany, suggesting a higher altitude may be a risk factor. Photo: Amy Bade, OD. Click image to enlarge. A study comparing uveal melanoma incidences in different German states found that...

A new study has linked those grisly tumors on Florida's teen turtles to pollution

Grisly tumors that have been afflicting young green sea turtles off Florida shores are likely worsened by onshore pollution that weaken the teen turtle’s immune systems. In a study published this week in the Journal of Wildlife Diseases, a team of Florida Atlantic University researchers examined turtles in the Indian River Lagoon over the last two decades, where about half have been infected with the herpes virus, Green Turtle Fibropapillomatosis, and sprout tumors. When they compared them to tumor-free turtles in more pristine waters off Cape Canaveral, they found the lagoon turtles had far weaker immune systems.