Over-engineering is the name of the game, so we picked the brains of the Tundra's design and engineering leads. It's always a good sign to see dirt splatters and grass still hanging onto on a pre-production truck, even after it's been shined up everywhere else to be put on display. That was the case with the 2022 Toyota Tundras on display at a pre-reveal sneak peek, and every time various Toyota reps apologized for it, I was like, no way, this is great to see.
The 2022 Toyota Tundra has finally been revealed, and it’s pretty nice. In addition to having a more modern look and an upgraded engine, the 2022 Toyota Tundra will be able to tow 12,000 pounds with a max payload capacity of 1,940. So how much does a fully loaded 2022 Toyota Tundra cost?
As one of the longest-running midsize truck nameplates, the 2022 toyota tacoma has proven to be a popular choice among buyers for over 25 years. Unbelievably durable and blessed with one of the best color palettes of any vehicle, the Tacoma appeals to both hardcore off-roaders and daily drivers. With such a wide range of capabilities, it all comes down to which Tacoma is right for your needs. Have a closer look at our trim guide to see which 2022 toyota tacoma version you should consider.
Toyota‘s full-size Tundra pickup truck is pretty big. Its new redesign brings to life many new features and little details the Tundra didn’t have before. After 15 years of the same generation, finally, a new-gen Toyota Tundra surfaces for 2022. This massive truck does not measure up to even the smallest trucks in some aspects, however. For instance, the gigantic 2022 Toyota Tundra TRD Pro can’t haul as much weight as the tiny Ford Ranger.
The Toyota Camry is one of the most popular cars on the road, and for good reason: It works. The Camry has shuffled people back and forth from the office to their house for four decades. Though, unlike the beloved Corolla, the Camry’s roots don’t spread too far into the performance side of things. Fortunately, Toyota is pushing to make everything fun, and the company’s 301 hp Toyota Camry is part of that list. Dubbed the Camry TRD, this Camry sports the same 3.5-liter naturally aspirated V6 that makes 301 hp that fits under the hood of other Camry models, though this Camry is lower and features a more aggressive body kit.
Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement
Proliferative diabetic retinopathy (PDR) is a sight-threatening diabetic complication in urgent need of new therapies. In this study we identify potential molecular mechanisms and target candidates in the pathogenesis of PDR fibrovascular tissue formation. We performed mRNA sequencing of RNA isolated from eleven excised fibrovascular membranes of type 1 diabetic PDR patients and two non-diabetic patients with rhegmatogenous retinal detachment with proliferative vitreoretinopathy. We determined differentially expressed genes between these groups and performed pathway and gene ontology term enrichment analyses to identify potential underlying mechanisms, pathways, and regulators. Multiple pro-angiogenic processes, including VEGFA-dependent and -independent pathways, as well as processes related to lymphatic development, epithelial to mesenchymal transition (EMT), wound healing, inflammation, fibrosis, and extracellular matrix (ECM) composition, were overrepresented in PDR. Overrepresentation of different angiogenic processes may help to explain the transient nature of the benefits that many patients receive from current intravitreal anti-angiogenic therapies, highlighting the importance of combinatorial treatments. Enrichment of genes and pathways related to lymphatic development indicates that targeting lymphatic involvement in PDR progression could have therapeutic relevance. Together with overrepresentation of EMT and fibrosis as well as differential ECM composition, these findings demonstrate the complexity of PDR fibrovascular tissue formation and provide avenues for the development of novel treatments.
In a way, the Toyota Tundra has always been an underdog. While it never captured record-breaking sales mostly because the Ford F-150 retained that status for as long as I can remember, the Toyota Tundra was always a prized truck for those who owned one long enough to attest to its durability and unmatched reliability. To remain relevant, because the Tundra was getting pretty old, Toyota has introduced the completely redesigned 2022 Toyota Tundra with new powertrains departing from the V8 formula that has worked for them since its initial introduction.
As trucks and cars are getting more complicated, the number of vehicles that are suitable for remote travel seems to be decreasing. One of the few manufacturers that can make these complicated trucks reliable is Toyota. The first reliability test mule will be the all-new 2022 Tundra TRD Pro with its complicated hybrid system.
There's been quite a lot of excitement surrounding the new Toyota Tundra pickup, and now that the Japanese automaker has revealed its 2022 full-size truck, we can see that the hype has not been unwarranted. As expected, it gets an upmarket new interior and a redesigned suspension system. But as...