#Stem Cell

What to Expect From Hematopoietic Stem Cell Transplantation

Hematopoietic stem cell transplantation is a procedure used to treat certain types of blood cancer and immune disorders. Hematopoietic stem cells produce red blood cells, white blood cells, and platelets, primarily in the bone marrow. If you are having this procedure, you would need to have a conditioning regimen before...
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Aided by stem cells, a lizard regenerates a perfect tail for first time in more than 250 million years

Newswise — Lizards can regrow severed tails, making them the closest relative to humans that can regenerate a lost appendage. But in lieu of the original tail that includes a spinal column and nerves, the replacement structure is an imperfect cartilage tube. Now, for the first time, a USC-led study in Nature Communications describes how stem cells can help lizards regenerate better tails.

Overhyped science behind fake stem cell treatments for Covid: Study

New York, Oct 16 (IANS) Amid the rush to find quick treatments for Covid-19 last year, the world saw a global race to find new stem cell-based treatments. Now, researchers report that such therapies were filled with violations of government regulations, inflated medical claims and distorted public communication. There are...

Drug discovery evolves: Jump-starting the transition from animal models to human preclinical models

Animal models, long the basis of academic research and preclinical drug discovery, continue to play an important role in advancing our understanding of basic pharmacology and bringing critical therapies to those in need. However, animal models have some natural drawbacks (e.g., not being humans) that hamper their ability to fully predict the interaction of new chemical entities with human physiology. Nonetheless, animal models remain the lynchpin of preclinical research the world over. Given the long-standing paucity of suitable human-based models to replace them, this should come as no surprise. Indeed, while both primary and immortalized human cells have long been available for in vitro research using standard tissue culture techniques, the primarily 2D nature of such in vitro studies is not sufficient to replicate human tissue’s complex structure and function.

Research Roundup: T-Cell Immune Response to COVID-19 Vaccines and More

Every week there are numerous scientific studies published. Here’s a look at some of the more interesting ones. T-Cell Immune Response to COVID-19 Vaccines and Natural Infections. Much of the discussions and news reports about immune responses to vaccines and COVID-19 revolve around antibody levels. Much less has been said...

Skin stem cells get moving for enhanced skin regeneration

Although sometimes hard to accept, with aging, many things in our bodies change. One of these is the ability of the skin to regenerate. Old skin is just not as good as young skin at healing wounds. However, the molecular and cellular mechanisms underlying this are largely unknown. Now, researchers from Japan have identified a mechanism to explain why this happens and potentially how it can be fixed.

CRISPR stem cell therapy grants lizards new regeneration powers

Lizards are famous for their regeneration, able to regrow their tails on demand, but the new tail is not quite perfect. Now, researchers at the University of Southern California (USC) have used stem cell therapy to let lizards grow better tails – bones, nerves and all – in an advance that could have implications for better wound healing in humans.
Business Insider

Why Jasper Therapeutics Stock Is Falling Today

Jasper Therapeutics Inc (NASDAQ:JSPR) is trading lower Thursday amid profit taking after the stock rallied roughly 120% on Wednesday. Jasper Therapeutics surged higher Wednesday after Oppenheimer analyst Jay Olson initiated coverage on the stock with an Outperform rating and announced a price target of $21. The Oppenheimer analyst cited the...

Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment

Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets produced from routine surgical discards using thermo-responsive cultureware. JCCs exhibit stable and high growth potential in vitro over passage 10, supporting possibilities for scale-up to mass production for commercialization. JCC sheets contain highly viable, densely packed cells, show no anchorage-independent cell growth, express mesenchymal surface markers, and lack MHC II expression. In nude rat focal osteochondral defect models, stable neocartilage formation was observed at 4 weeks by JCC sheet transplantation without abnormal tissue growth over 24 weeks in contrast to the nontreatment group showing no spontaneous cartilage repair. Regenerated cartilage was safranin-O positive, contained type II collagen, aggrecan, and human vimentin, and lacked type I collagen, indicating that the hyaline-like neocartilage formed originates from transplanted JCC sheets rather than host-derived cells. This study demonstrates the safety of JCC sheets and stable hyaline cartilage formation with engineered JCC sheets utilizing a sustainable tissue supply. Cost-benefit and scaling issues for sheet fabrication and use support feasibility of this JCC sheet strategy in clinical cartilage repair.
Harvard Health

R&D alliance with Resilience to advance manufacture of complex medicines

Harvard University and National Resilience, Inc. (Resilience), a manufacturing and technology company, have established a five-year R&D alliance with a $30 million commitment from Resilience directed toward the development of complex medicines, including biologics, vaccines, nucleic acids, and cell and gene therapies. Under the alliance agreement coordinated by Harvard’s Office...