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#Neuroprotection

science.org

The GABA receptor mediates neuroprotection by coupling to G

Activation of GABABR, the G protein–coupled receptor for the inhibitory neurotransmitter GABA, is thought to be neuroprotective through exclusive engagement of Gi/o. However, Wang et al. found that GABABR also engaged G13 to differentially activate the MAPK pathway kinase JNK. In cultured cerebellar granule neurons, this G13-mediated pathway increased the abundance of the postsynaptic scaffolding protein PSD95 and enhanced neuronal survival under low-potassium conditions. The authors further uncovered biological synergy between the two G protein–mediated pathways, with different kinetics in agonist responses. The findings reveal how GABA can mediate neuroprotection through multiple synergistic pathways that depend on distinct G proteins.
SCIENCE
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thelancet.com

Early Biomarkers of Hypoxia and Inflammation and Two-Year Neurodevelopmental Outcomes in the Preterm Erythropoietin Neuroprotection (PENUT) Trial

In the Preterm Erythropoietin (Epo) NeUroproTection (PENUT) Trial, potential biomarkers of neurological injury were measured to determine their association with outcomes at two years of age and whether Epo treatment decreased markers of inflammation in extremely preterm (<28 weeks’ gestation) infants. Methods. Plasma Epo was measured (n=391 Epo, n=384 placebo)...
MEDICAL SCIENCE
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