A.I. Like ChatGPT Is Revealing the Insidious Disease at the Heart of Our Scientific Process

The language in Nature was pretty mild as far as freakouts go. ChatGPT and other similar A.I. tools, the editors wrote, threaten “the transparency and trust-worthiness that the process of generating knowledge relies on … ultimately, research must have transparency in methods, and integrity and truth from authors.” The editor of Nature’s chief rival, Science, similarly blew his stack in a most genteel manner: “An AI program cannot be an author. A violation of these policies will constitute scientific misconduct no different from altered images or plagiarism of existing works,” he wrote.
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From Ancient Pits to Smart Latrines: 'Unloading' the History of Toilets

Toilets are everyone's best friend in the morning. And you know exactly why. Talking about it may not sound so pleasant, but this mundane daily object has a rich history that is worth "unloading." Most people claim that English plumber Thomas Crapper was the inventor of the toilet after building...
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Inspired by Nature, Guzman Paints from the Heart

Luis Guzman has known since he can remember that his hands and heart were meant to paint. This mostly self-taught artist thinks he probably inherited the ability from his father, who would often draw in front of him. It wasn’t until he was 19 though, six years after he moved to the United States, that he went to his first art show and fell in love with art. It also sparked his curiosity to explore the artist in him that was begging to be let out.

Vevo reveals plans to celebrate hip-hop turning 50

Vevo is joining in on the celebration of hip-hop’s anniversary. The music video network is teaming up with artists across the genre for some specialized and original content. Artists including A$AP Rocky, Common, Cypress Hill, De La Soul, Lil Wayne, Ludacris, Naughty by Nature, Salt-N-Pepa and Public Enemy have...

To improve existing antibiotics and develop new antimicrobial treatments

The lack of effective antibiotics is an increasingly serious threat to global health. In recent decades, only a few new antimicrobial agents have been able to reach the market. Designing new functionalities for already known antibiotics —or those that have fallen out of use due to toxicity— is one of the strategies to make up for this drug shortage. Now, a study conducted by teams of the University of Barcelona and the Institute for Bioengineering of Catalonia (IBEC) has improved known antibiotics to make them more effective in much smaller doses. This finding opens up the possibility of developing new antimicrobial treatments in an innovative and affordable way.

Motivation, Food, Nature, Animals & Birds, Festival

Perfect Review : Be Inspire and Get Inspired, Follow the Perfect review blog for National days, News and Entertainment. National Squirrel Appreciation DayNational Penguin Day.


Read the paper in NATURE

The economy is so bad people are selling pictures of their feet

Perhaps you are bewildered at the fact that there are actually people out there that want to pay for images of feet – and that you can really start making money if you know how and where to sell them. According to a study from Nature, 33% of all...

FREE Nature’s Way Products

Try FREE Nature’s Way Products! Nature’s Way offers a wide range of solutions for maintaining overall wellness, including relieving cold symptoms, boosting immunity, and promoting healthy digestion, heart health, and more. If you’re looking for a holistic approach to wellness for yourself and your family, Nature’s Way is here to help. Apply today for a chance to try their products and see for yourself how they can support busy families in achieving optimal health and well-being.

Scientists define genes to increase cancer immunotherapy efficiency

#Scientistsdefine #genesincrease #cancerimmunotherapy. Fundamental Inferences Researchers have discovered that a cancer cells can allow the expression of an immune growth gene to be not affected by immunotherapy or to develop resistance during treatment. Silence or blocking the expressing protein has increased the sensitivity of cancer cells to immunotherapy in multiple preclinic models Boston – immune control point inhibitors are important drugs that increase the response of the immune system to various cancers, but some patients cancer cells are not affected by drugs or develop resistance during treatment. Massachusetts, a founding member Mass General Brigham, Massachusetts General Hospital , MIT and Harvard’s Broad Institute recently identified found the gene escaping from an active immunity in some of these cells.The gene increased the sensitivity cells to immunotherapy. Genes encourages protein called tank binding kinase 1 , a multifunctional enzyme that has settled role in coordinating innate immune reactions against viruses and other invading pathogens. Senior writers who are assisted by Assistant Professor Broad Institute Harvard Medical Faculty at Harvard Faculty of Cancer Center in Nature magazine and Nature magazine, Russell W. Jenkins, MD, PHD, Robert T. Manguso, alsoA researcher MGH Cancer Research Center found that deletion of TBK1 gene’s tumors sensitive to immune attack. In addition, in mouse cancer models, treatment with a pharmacological inhibitory that blocks activity of TBK1 protein has exceeded resistance of tumors to immunotherapy without causing weight loss or other systemic toxicity symptoms.This strategy also worked in patient’s own cancer cells and immune cells, which are derived from patient with “live biopsies”, organotypic tumor spheroids or new patient -based tumor models called PDOTS. Mechanically, mechanically, TBK1 found tumor cells sensitive to the effects of immune molecules, including tumor necrosis factor and interferon, increased the response to immunotherapy. “It is unreasonable that TBK1 loss will increase immunotherapy, because this protein is often thought to encourage inflammation. Manguso, the co -chairman of the tumor immunotherapy discovery engine project in Broad, should make a tumor less sensitive to treatment, not more,” he says. “However, we found that closing TBK1 caused tumor cells to die by re -programming the response to the immune signals called cytokine. The second effect is becoming critical in this context.” “Our results show that targeting TBK1 is a new and effective strategy to overcome the resistance to cancer immunotherapy,” Jenkins says. “Our study also provides a framework for evaluating other potential immune goals in multi -model systems using a combination of genetic and pharmacological tools.” Among the joint writers of EK MGH and Broad Institute, Yi Sun, Or-Yam Revach, Seth Anderson, Emily Kessler, Clara Wolfe, Anne Jenney, Thomas G.R.Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter Du, Prink Sindurakar, Jun Tian, Arnav Mehta, Moshe Sade-Feldman, Thomas Lasalle, Tatyana Sharova, Hongyan Xie, William A. Michaud, William A. MichaudRodrigo Saad –beretta, Kathleen B. Yates, Arvin Ichata -Sellve, Mack Y. Su, Angelina Cicerchia, Martin Q. Rasmussen, Samuel J. Clempner, Dejan Juric, Sara I. Pai, David M. Miller, Jonathan H. Chen, Karin Pelka, Dennie T. Frederick, Debattama R. Sen, David E. Fisher, Ryan B. Corcoran, Nir Hacohen, Keith T. Flaherty and Genevieve Boland. This study was supported by the National Institute of Health/National Cancer Institute , Melanoma Alliance Young Researcher Award .Grunebaum Cancer Research Foundation Faculty Scholarship , Termeer Early Career Scholarship in System Pharmacology and Steven B. and Joan W. Belkin. About Massachusetts General Hospital Massachusetts Hospital, founded 1811, is original largest training hospital Harvard Medical School.Mass General Research Institute conducts largest hospital -based research program country with an annual research activities over $ 1 billion and consists more than 9,500 researchers working more than 30 institutes, center department.Mass General, July 2022 U.S.News & World Report ranked 8th “Best Hospitals America” list.MGH is a founding member Mass Brigham health system.

“My Garden of a Thousand Bees,” January 29

Sunday, January 29, 2 p.m. St. Ambrose University's Galvin Fine Arts Center, 2101 North Gaines Street, Davenport IA. A beautiful and informative documentary that found its inspiration during the shelter-in-place phase of the VOVID-19 pandemic, My Garden of a Thousand Bees serves as the second presentation in River Action's annual QC Environmental Film Series, the film created when wildlife filmmaker Martin Dohrn set out to record all the bees he could find in his tiny urban garden in Bristol, England, filming them with one-of-a-kind lenses he forged on his kitchen table.

Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

Prolonged interferon (IFN) signaling in cancer cells can promote resistance to immune checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to coordinate resistance is unclear. We show that, across human and/or mouse tumors, immune dysfunction is associated with cancer cells acquiring epigenetic features of inflammatory memory. Here, inflammatory memory domains, many of which are initiated by chronic IFN-γ, are maintained by signal transducer and activator of transcription (STAT)1 and IFN regulatory factor (IRF)3 and link histone 3 lysine 4 monomethylation (H3K4me1)-marked chromatin accessibility to increased expression of a subset of IFN-stimulated genes (ISGs). These ISGs include the RNA sensor OAS1 that amplifies type I IFN (IFN-I) and immune inhibitory genes. Abrogating cancer cell IFN-I signaling restores anti-programmed cell death protein 1 (PD1) response by increasing IFN-γ in immune cells, promoting dendritic cell and CD8+ T cell interactions, and expanding T cells toward effector-like states rather than exhausted states. Thus, cancer cells acquire inflammatory memory to augment a subset of ISGs that promote and predict IFN-driven immune dysfunction.

We’re Disrupting Disruption

The Sunday Times featured an op-ed by Mark Britnell, a professor at the UCL Global Business School for Health, with the headline Our creaking NHS can’t beat its admin chaos without a tech revolution. Substitute “U.S. healthcare system” for “NHS” and the headline still would work, as would most of the content.

Turbulent magnetic reconnection generated by intense lasers

Turbulent magnetic reconnection is believed to occur in astrophysical plasmas, and it has been suggested to be a trigger of solar flares. It often occurs in long stretched and fragmented current sheets. Recent observations by the Parker Solar Probe, the Solar Dynamics Observatory and in situ satellite missions agree with signatures expected from turbulent reconnection. However, the underlying mechanisms, including how magnetic energy stored in the Sun's magnetic field is dissipated, remain unclear. Here we demonstrate turbulent magnetic reconnection in laser-generated plasmas created when irradiating solid targets. Turbulence is generated by strongly driven magnetic reconnection, which fragments the current sheet, and we also observe the formation of multiple magnetic islands and flux-tubes. Our findings reproduce key features of solar flare observations. Supported by kinetic simulations, we reveal the mechanism underlying the electron acceleration in turbulent magnetic reconnection, which is dominated by the parallel electric field, whereas the betatron mechanism plays a cooling role and Fermi acceleration is negligible. As the conditions in our laboratory experiments are scalable to those of astrophysical plasmas, our results are applicable to the study of solar flares.

Food, Nature, and Health Transitions—Repeatable Country Models

This report originally appeared on the World Economic Forum. High-performing food systems provide healthy and nutritious diets. They create dignified livelihoods for producers and benefit the economy. They mitigate and adapt to climate change, and safeguard nature and biodiversity. Today our food systems fall far short of these goals. Food...

Methane and Rising Temperatures

While carbon-dioxide is the major greenhouse gas by volume, methane is more potent and its release is still rising—rising rapidly in fact. Scientists have calculated that over the next century the global-heating potential of methane is 28 times higher than for carbon dioxide. Animal Farts. About 30 percent of...