Personal Financelexblog.com

MTC Uniformity Committee update — project on sales taxation of digital goods moves forward

On July 28, 2021, the Uniformity Committee of the Multistate Tax Commission’s (MTC) advanced the new project on Sales Taxation of Digital Goods (the Project). Specifically, the Standing Subcommittee recommended MTC staff draft an outline for a white paper that will explore issues concerning the state taxation of digital products and to provide guidance on the matter in pursuit of uniformity. The Uniformity Committee approved the Subcommittee’s recommendation, and the outline will be presented at the MTC’s November meeting, where state representatives will have the opportunity to provide commentary.
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Logan, UTHerald-Journal

Cache Valley People: Meet 'Nutmeg,' aka Ted and Meg Erekson

Editor’s Note: This article is part of a series of stories planned by Cache Valley freelance writer Cindy Knowles based on the idea that everyone has an interesting story to tell. She met Meg and Ted Erekson while visiting the Cache Valley Gardeners’ Market. Seeing the Ereksons in their matching...
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Task force approves action plan for Bay Area transit network

The Metropolitan Transportation Commission (MTC) Blue Ribbon Task Force this week approved 27 near-term actions to be taken by MTC and other transportation agencies in the coming months to make the Bay Area’s public transportation network more connected and efficient. Approval of this set of actions marks the culmination of...
TrafficStreetsblog Capitol Hill

Update: Progress Towards Seamless Transit

Different fares, different agencies, few if any free transfers or discounts, and uncoordinated schedules–taking transit in the Bay Area is challenging, to say the least. That’s why Seamless Bay Area has long campaigned for major governance reform and the creation of an umbrella organization to collect fares. Seamless is dedicated to creating a more European-style system where transit riders don’t have to decipher and pay for nearly 30 separate bus, ferry, and rail operators.
San Diego, CADaily Aztec

Musical Theatre Club elects new all-women board

San Diego State Musical Theatre Club (MTC) has elected new members to their current board for the 2021-22 academic year. Anelaokalani Lee, a psychology major, is the newly elected secretary on the MTC board. She claims that doing musical theatre in high school changed her life, because she felt she wasn’t going to get a lot of chances to do musical theatre, until she joined MTC.
Health Servicesthenewjournalandguide.com

STOP’s Mobile Telehealth Clinic Will Aid Rural Communities

After months of planning and fundraising. STOP Inc. is preparing to launch its Mobile Telehealth Clinic (MTC) to address healthcare inequalities in the rural areas of Western Tidewater, Southampton County, and small enclaves such as the City of Franklin and portions of Isle of Wight. Funding from the Bank of...

EGR2-mediated regulation of mA reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are upregulated in most cancers and mediates the enhancement of m6A-modified mRNAs stability. However, the mechanisms of IGF2BPs in renal cell cancer (RCC) still remain unclear. Bioinformatic analysis and RT-qPCR were performed to evaluate the expression of IGF2BPs and m6A writer Wilms tumor 1-associating protein (WTAP) in RCC samples and its correlation with patient prognosis. In vitro, in vivo biological assays were performed to investigate the functions of IGF2BPs and WTAP in RCC. Chromatin immunoprecipitation-qPCR (ChIP-qPCR) combined with bioinformatics analysis and following western blot assay, dual-luciferase reporter assays were performed to validate the regulatory relationships between transcription factor (TF) early growth response 2 (EGR2) and potential target genes IGF2BPs. RNA sequencing (RNA-seq), methylated RNA immunoprecipitation-qPCR (MERIP-qPCR), RIP-qPCR, m6A dot blot, and dual-luciferase reporter assays combined with bioinformatics analysis were employed to screen and validate the direct targets of IGF2BPs and WTAP. Here, we showed that early growth response 2 (EGR2) transcription factor could increase IGF2BPs expression in RCC. IGF2BPs in turn regulated sphingosine-1-phosphate receptor 3 (S1PR3) expression in an m6A-dependent manner by enhancing the stability of S1PR3 mRNA. They also promoted kidney tumorigenesis via PI3K/AKT pathway. Furthermore, IGF2BPs and WTAP upregulation predicted poor overall survival in RCC. Our studies showed that the EGR2/IGF2BPs regulatory axis and m6A-dependent regulation of S1PR3-driven RCC tumorigenesis, which enrich the m6A-modulated regulatory network in renal cell cancer. Together, our findings provide new evidence for the role of N6-methyladenosine modification in RCC.
Willacy County, TXraymondville-chronicle.com


MTC WILLACY COUNTY REGIONAL DETENTION FACILITY has recognized General Maintenance Worker Stephen Anderson as the 2021 Employee of the 2nd Quarter. Anderson is pictured with acting Chief of Security Joanna Gonzales and Warden Jose Luna.
San Francisco, CASan Mateo Daily Journal

Blue Ribbon Task Force approves transit action plan reform in the Bay Area

The Metropolitan Transportation Commission Blue Ribbon Task Force has ratified its long-awaited Transit Transformation Action Plan to improve the Bay Area transit system in the short and long term, with representatives celebrating the milestone. I do believe the Transformation Action Plan is a document we should all be extremely proud...
San Mateo County, CASan Mateo Daily Journal

Caltrain, SamTrans will receive federal funding

Caltrain and SamTrans will receive around $56 million total in federal funding from the American Rescue Plan Act for COVID-19 financial assistance following MTC allocation approval, although the train agency is hoping for more. David Canepa, president of the San Mateo County Board of Supervisors and member of the Metropolitan...

Blue Ribbon Task Force Wraps Work on Transit Issues

The Blue Ribbon Transit Recovery Task Force convened by the Metropolitan Transportation Commission (MTC) recently wrapped up its work by approving 27 near-term actions to be taken by MTC, transit agencies, county transportation agencies and others in the coming months to improve the Bay Area’s public transportation network. Approval of this set of actions marks the culmination of a 14-month effort that began in May 2020 when the task force accepted a three-stage mission to help the Bay Area transit network adjust to new conditions created by the pandemic.
Manatee County, FLLongboat Observer

MTC to have new firing range and driving pad in Myakka

For the past four years, the Manatee Technical College Law Enforcement Academy has been searching for a property where it could construct a firing range and driving course to train recruits. In the meantime, recruits have had to travel to Sarasota or St. Petersburg for training that costs thousands of...
New York City, NYBroadway.com

Odds & Ends: Cynthia Erivo & More Join Roster for NYC Reopening Concert

(Photo by Caitlin McNaney for Broadway.com) Here's a quick roundup of stories you might have missed recently. Lineup Announced for We Love New York City Concert. Details and more stars have been announced for We Love New York City: The Homecoming Concert. As previously reported, Bruce Springsteen, Jennifer Hudson and Paul Simon will take the stage in a show celebrating the reopening of New York City. Mayor Bill de Blasio announced additional details and names on July 27. The concert will take place on the Great Lawn in Central Park on August 21 and feature Cynthia Erivo, Barry Manilow, Jon Batiste, Andrea Bocelli, LL COOL J, Elvis Costello, Lucky Daye, Earth, Wind & Fire, the New York Philharmonic, Polo G and more. 80 percent of tickets will be free and become available here on August 2 at 10AM ET. Proof of a COVID-19 vaccine is required to attend. “This is going to be an historic, monumental moment for all New Yorkers and all Americans," Mayor de Blasio said in a statement.
Waltham, MAmiddlesexsheriff.org

Waltham Police Department, Middlesex Sheriff’s Office partner on interactive, scenario-based training

Fifty-five (55) members of the Waltham Police Department (WPD) recently completed two weeks of interactive, scenario-based training in partnership with the Middlesex Sheriff’s Office (MSO), utilizing the office’s Mobile Training Center (MTC), Police Chief Kevin O’Connell and Sheriff Peter J. Koutoujian announced today. This marked the fifth consecutive year Waltham...

Vandetanib and Cabozantinib Deemed Effective in Real-World Study of Medullary Thyroid Cancer

Vandetanib and cabozantinib are “effective treatment options” in most patients with medullary thyroid cancer (MTC), according to researchers who conducted a real-world analysis of the drugs. The retrospective analysis, published in Thyroid, included patients with metastatic or locally advanced MTC who received treatment with one or both of the tyrosine...