#Major Depression

Different Types of Depression: An Overview

Although depression is a common condition, it can be a confusing disorder to understand, as it has multiple types, all with unique symptoms and ranges of severity. In this article, read about the different types of depression, their causes, symptoms, and prevention and treatment methods. What Is Depression?. Depression is...
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Psych Centra

Fibromyalgia and Depression: What’s the Link?

Fibromyalgia and depression often occur together, and that’s not a coincidence. If you’re living with fibromyalgia, you are probably all too familiar with the pain. You may also feel isolated, alone, or like no one understands what you are going through. Unfortunately, these combined effects can lead to mental health...
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Psych Centra

Is Depression Affecting Your Decision Making?

Living with depression can make even the smallest decisions a challenge, but there are ways to help make decision making easier. Feelings of loneliness or sadness, a loss of interest in things you once enjoyed, and feelings of hopelessness — these are all hallmarks of depression. But these are not...
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What is seasonal depression?

GRAND JUNCTION, Colo. (KKCO) - This time of year, when the sun is out for fewer hours of the day, seasonal depression, or seasonal affective disorder, starts to make an appearance. “Around the time when the time changes, that’s when we start to get a lot of clients who are...
Pro Wrestling Torch

GUEST ARTICLE: It Ain’t 1987 No More: Eddie Kingston and Depression Treatment in Wrestling

SPOTLIGHTED PODCAST ALERT (YOUR ARTICLE BEGINS A FEW INCHES DOWN)... A few weeks ago, Players Tribune published a fascinating, poignant piece by Eddie Kingston, about both his journey in pro wrestling and in life more broadly. Eddie’s disclosures about his experiences with depression and panic attacks offer important lessons for understanding and treating these problems. (All sections in italics are quotes from Eddie’s article.)

Your Medical History Could Help You Pick the Right Anti-Depressant

Research indicates that a person's medical background may impact which antidepressant will fit their needs best. The best antidepressant had an average remission rate that was 1.5 times higher than the average antidepressant, and 20 times higher than the worst antidepressant for that subgroup. These findings may support more effective...

How CBD Oil Help Improve Singer’s Performance

Everyone wants to stay calm throughout the day, most especially in times of important events. One of the greatest examples is singers. They must maintain their overall health, both the physical and mental aspects. One way to maintain such things is through hemp CBD oil intake. Is CBD effective in...

How I Use Writing and Music for Depression

As anyone who has lived with almost any medical condition or ailment will tell you, there is almost always more than one way to approach your treatment. This is good news, because as individuals we are unique in our own ways, and what works for one person may not work for another.
Neuroscience News

Looking to Mitochondria for Clues About Depression

Summary: People with untreated depression have lower levels of mitochondrial proteins. For those who responded to the SSRI antidepressants, the proteins returned to a normal level, but showed no increase in those who did not respond to medication. Source: UCSF. Depression is a global issue. The World Health Organization (WHO)...

Stressed, or depressed? How to tell the difference

If you think you are experiencing symptoms of stress or depression, you are not alone. A Gallup poll revealed that 57% of U.S. and Canadian workers experienced daily stress in 2020, the highest levels globally. About 17.3 million adults in the U.S. report having had at least one major depressive episode.

Looking to the cell's power generators for clues to depression

Depression is a global issue. The World Health Organization (WHO) estimates that 15 percent of people will experience a disabling bout of depression at some point in their lives. Despite an array of treatments that includes talk therapy, pharmaceuticals, and various forms of magnetic and electronic stimulation, finding the best treatment is often a trial-and-error process, and many patients never get relief from their symptoms.

Treatment of sleep loss may prevent depression in the elderly

A new study from UCLA Health finds that cognitive-behavioral therapy (CBT-I) prevents major depression and reduces the likelihood of depression in adults over the age of 60 with insomnia by more than 50%. I did. Over 10% of community-dwelling adults over the age of 60 experience major depression later in...

Writer’s list helps battle seasonal depression

I once counted myself among the lucky few who strode through life, high above the depression and anxiety that can ebb and flow for so many of us. But the fact of aging, coupled with the heartbreak of parenthood and a painful, protracted divorce, combined to wear me down over the past decade. I’ve never been debilitated, but I have been down to the point of wondering how and when the heavy fog might lift.

5 Major Improvements You'll See From Doing Yoga Every Day, Says Science

It's safe to say at this point that yoga is more than a flash in the wellness pan or yet another fleeting fitness fad. After all, this ancient practice combining precise physical poses, deep breathing, and mental focus dates back over 5,000 years! If people have been practicing yoga for that long, there must be something to it.

Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial

Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive randomization to determine the optimal dose for the probability of treatment response (≥50% improvement from baseline on the Montgomery-Ã…sberg Depression Rating Scale) 7 days after a 40"‰min intravenous (IV) infusion of ketamine 0.1"‰mg/kg (KET 0.1), 0.25"‰mg/kg (KET 0.25), or 0.5"‰mg/kg (KET 0.5), compared to midazolam 0.03"‰mg/kg (MID) as an active placebo. The goal of this study was to identify the best dose to carry forward into a larger clinical trial. Response durability at day 28, safety and tolerability, and effects on cortical excitation/inhibition (E/I) ratio using resting electroencephalography gamma and alpha power, were also determined. Thirty-three medication-free US military veterans (mean age 62; range: 55"“72; 10 female) with LL-TRD were randomized double-blind. The trial was terminated when dose superiority was established. All interventions were safe and well-tolerated. Pre-specified decision rules terminated KET 0.1 (N"‰="‰4) and KET 0.25 (N"‰="‰5) for inferiority. Posterior probability was 0.89 that day-seven treatment response was superior for KET 0.5 (N"‰="‰11; response rate = 70%) compared to MID (N"‰="‰13; response rate = 46%). Persistent treatment response at day 28 was superior for KET 0.5 (response rate = 82%) compared to MID (response rate = 37%). KET 0.5 had high posterior probability of increased frontal gamma power (posterior probability = 0.99) and decreased posterior alpha power (0.89) during infusion, suggesting an acute increase in E/I ratio. These results suggest that 0.5"‰mg/kg is an effective initial IV ketamine dose in LL-TRD, although further studies in individuals older than 75 are required.

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6"‰Â±"‰6.5 years, 5 women) and 13 healthy volunteers (34.8"‰Â±"‰10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, VT) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 VT in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r"‰="‰âˆ’0.85, p"‰="‰0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.

To Prevent Elderly Depression, Target Sleep

RCT finds lowering incident insomnia cut risk of depression. Maybe the best way to prevent depression in the elderly and others is to not talk about depression at all, but focus instead on a risk factor for depression—insomnia. Insomnia increases the risk for depression in older adults, but a randomized,...

Podcast: Opening Up About My Struggle With Recurring Depression

A health care leader shares her story of living with major depression and calls for better treatments. Read by author Nora Super, senior director of the Milken Institute Center for the Future of Aging and the executive director of the Milken Institute Alliance to Improve Dementia Care. “I decided to...