MedPage Today

Researchers Call Out 'Nepotistic Behavior' at Biomedical Journals

Some biomedical journals may be practicing "nepotistic behavior," a new study suggested. In a random sample of 98 journals with a disproportionate amount of publications by one author, that author was on the editorial board in 61% of cases, reported Clara Locher, PharmD, PhD, of the University of Rennes in France, and colleagues. In 26% of cases, the most prolific author was also the editor-in-chief of the journal.
Picture for Researchers Call Out 'Nepotistic Behavior' at Biomedical Journals

Abrupt Discontinuation From Long-Term Opioid Therapy in Massachusetts, 2015–2018

In response to the opioid overdose crisis, providers were urged to taper and discontinue patients from long-term opioid therapy; however, abrupt discontinuation may lead to poor health outcomes. This study aims to determine abrupt and tapered discontinuation rates and identify the patient and provider characteristics associated with abrupt discontinuation. Methods.
Picture for Abrupt Discontinuation From Long-Term Opioid Therapy in Massachusetts, 2015–2018

Contributor: CMS Has Decided to Put Its Muscle Behind Glycemic Management—Why Now?

CMS' introduction of 3 new electronic clinical quality measures, 2 of which are focused on inpatient glycemic management, signal a strong commitment to shine a light on this often-overlooked area, according to the chief medical officer at Glytec. CMS recently completed its annual update of payment policies and rates for...

Variability in biopsy quality informs translational research applications in hepatocellular carcinoma

In the era of precision medicine, biopsies are playing an increasingly central role in cancer research and treatment paradigms; however, patient outcomes and analyses of biopsy quality, as well as impact on downstream clinical and research applications, remain underreported. Herein, we report biopsy safety and quality outcomes for percutaneous core biopsies of hepatocellular carcinoma (HCC) performed as part of a prospective clinical trial. Patients with a clinical diagnosis of HCC were enrolled in a prospective cohort study for the genetic, proteomic, and metabolomic profiling of HCC at two academic medical centers from April 2016 to July 2020. Under image guidance, 18G core biopsies were obtained using coaxial technique at the time of locoregional therapy. The primary outcome was biopsy quality, defined as tumor fraction in the core biopsy. 56 HCC lesions from 50 patients underwent 60 biopsy events with a median of 8 core biopsies per procedure (interquartile range, IQR, 7"“10). Malignancy was identified in 45/56 (80.4%, 4 without pathology) biopsy events, including HCC (40/56, 71.4%) and cholangiocarcinoma (CCA) or combined HCC-CCA (5/56, 8.9%). Biopsy quality was highly variable with a median of 40% tumor in each biopsy core (IQR 10"“75). Only 43/56 (76.8%) and 23/56 (41.1%) samples met quality thresholds for genomic or metabolomic/proteomic profiling, respectively, requiring expansion of the clinical trial. Overall and major complication rates were 5/60 (8.3%) and 3/60 (5.0%), respectively. Despite uniform biopsy protocol, biopsy quality varied widely with up to 59% of samples to be inadequate for intended purpose. This finding has important consequences for clinical trial design and highlights the need for quality control prior to applications in which the presence of benign cell types may substantially alter findings.
DVM 360

Repurposing common endocrine tests for use in canine critical illness

At the intersection of endocrinology and critical illness, these case studies examine endocrine biomarkers that accompany severe illness and incipient recovery. The integration of endocrinology and critical illness has generated important new insights into the complex and constantly changing endocrine environment accompanying severe illness. These studies have uncovered endocrine biomarkers of disease severity and harbingers of incipient recovery. Studies performed 60 years ago on adrenalectomized dogs demonstrated that the adrenal response to shock and critical illness was essential for survival.1 Moreover, nonthyroidal illness (NTI) in dogs is a well-known cause of euthyroid sick syndrome and the effects of severe illness on lowering thyroid hormones have been well-described.2.
Medscape News

Exercise Training and Reproductive Outcomes in Women With Polycystic Ovary Syndrome

Jamie L. Benham; Jane E. Booth; Bernard Corenblum; Steve Doucette; Christine M. Friedenreich; Doreen M. Rabi; Ronald J. Sigal. Objective: Exercise is recommended for polycystic ovary syndrome (PCOS), but the most effective exercise prescription is unclear. This trial compared effects of high-intensity interval training (HIIT), continuous aerobic exercise training (CAET) and no-exercise control on reproductive, anthropometric and cardiometabolic outcomes in PCOS.

Patient-reported benefit from proposed interventions to reduce financial toxicity during cancer treatment

Support Care Cancer. 2021 Nov 25. doi: 10.1007/s00520-021-06697-6. Online ahead of print. INTRODUCTION: Financial toxicity is common and pervasive among cancer patients. Research suggests that gynecologic cancer patients experiencing financial toxicity are at increased risk for engaging in harmful cost-coping strategies, including delaying/skipping treatment because of costs, or forsaking basic needs to pay medical bills. However, little is known about patients’ preferences for interventions to address financial toxicity.

Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study

In patients with metastatic colorectal cancer (mCRC), baseline circulating tumour DNA (ctDNA) variant allele fraction (VAF) might serve as a surrogate of disease burden and should be evaluated in comparison with CEA and RECIST-defined sum of target lesions. Methods. In this pre-planned analysis of the VALENTINO trial, we included patients...

Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience

International Journal of Obesity (2021)Cite this article. Randomized clinical trials have proven the efficacy and safety of Food and Drug Administration (FDA) approved anti-obesity medications (AOMs) for long-term use. It is unclear whether these outcomes can be replicated in real-world clinical practice where clinical complexities arise. The aim of this study was to evaluate the effectiveness and side effects of these medications in real-world multidisciplinary clinical practice settings.

Sociodemographic factors associated with time to discharge for hospitalised patients with asthma and asthma exacerbation using the Ghana Health Service District Information Management System 2 (DHIMS-2) database, 2012-2017

BMJ Open Respir Res. 2021 Nov;8(1):e001034. doi: 10.1136/bmjresp-2021-001034. OBJECTIVE: Data on asthma hospitalisations are a useful source of patient morbidity information. In Ghana, the length of stay (LoS) and sociodemographic factors of patients hospitalised for asthma and its exacerbation are understudied. We aimed to investigate the time to discharge and assessed factors associated with length of hospital stays of asthmatics in Ghana.

Variation in COVID-19 Mortality in the US by Race and Ethnicity and Educational Attainment

JAMA Netw Open. 2021 Nov 1;4(11):e2135967. doi: 10.1001/jamanetworkopen.2021.35967. IMPORTANCE: Racial and ethnic inequities in COVID-19 mortality have been well documented, but little prior research has assessed the combined roles of race and ethnicity and educational attainment. OBJECTIVE: To measure inequality in COVID-19 mortality jointly by race and ethnicity and educational...

Comparison of three surgical techniques for internal angular dermoid cysts: a randomized controlled trial

To compare the outcomes of three techniques for removing internal angular dermoid cysts: lid crease, sub-brow, and direct mini-incision. In this single-center trial, 47 children with internal angular dermoids were enrolled and randomly assigned to one of three surgical groups: group A, sub-brow, group B, lid crease, and group C, direct mini-incision. Outcome measures were operative time, postoperative scar quality using Stony Brook Scar Evaluation Scale (SBSES), scar visibility, and family satisfaction.

New Accelerate Pheno® System Multi-Center Study Published In Clinical Infectious Diseases

TUCSON, Ariz., Nov. 22, 2021 /PRNewswire/ -- Accelerate Diagnostics, Inc. (AXDX) - Get Accelerate Diagnostics, Inc. Report today announced the publication of its Improving Outcomes and Antibiotic Stewardship (IOAS) Study in the journal Clinical Infectious Diseases . The multi-center, real-world study compared data before and after implementation of the Accelerate Pheno system across several hospitals to determine its impact on the treatment of patients with bloodstream infections. The data showed statistically significant reductions in time to optimal antimicrobial therapy, modification, and de-escalations associated with widespread patient benefits.

A national cohort study (2000"“2018) of long-term air pollution exposure and incident dementia in older adults in the United States

Air pollution may increase risk of Alzheimer's disease and related dementias (ADRD) in the U.S., but the extent of this relationship is unclear. Here, we constructed two national U.S. population-based cohorts of those aged ≥65 from the Medicare Chronic Conditions Warehouse (2000"“2018), combined with high-resolution air pollution datasets, to investigate the association of long-term exposure to ambient fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) with dementia and AD incidence, respectively. We identified ~2.0 million incident dementia cases (N"‰="‰12,233,371; dementia cohort) and ~0.8 million incident AD cases (N"‰="‰12,456,447; AD cohort). Per interquartile range (IQR) increase in the 5-year average PM2.5 (3.2"‰Âµg/m3), NO2 (11.6 ppb), and warm-season O3 (5.3 ppb) over the past 5 years prior to diagnosis, the hazard ratios (HRs) were 1.060 (95% confidence interval [CI]: 1.054, 1.066), 1.019 (95% CI: 1.012, 1.026), and 0.990 (95% CI: 0.987, 0.993) for incident dementias, and 1.078 (95% CI: 1.070, 1.086), 1.031 (95% CI: 1.023, 1.039), and 0.982 (95%CI: 0.977, 0.986) for incident AD, respectively, for the three pollutants. For both outcomes, concentration-response relationships for PM2.5 and NO2 were approximately linear. Our study suggests that exposures to PM2.5 and NO2 are associated with incidence of dementia and AD.
Medscape News

Endoscopic Resection of Esophageal Cancer Requires Long-term Postop Surveillance

LAS VEGAS – Although endoscopic resection of T1 esophageal adenocarcinoma (EAC) is associated with excellent overall survival, recurrence can occur years later, emphasizing the need for long-term surveillance, according to investigators. Recurrence was about twice as common among patients lacking complete remission of intestinal metaplasia (CRIM) upon follow-up, reported lead...

Betting Opportunities for Week 11 NFL Matchups

Each week during the 2021 NFL season, Sports Info Solutions will highlight the spread of three games including Monday Night Football. Get Free Betting Recommendations & Premium Content, 100% Free. Green Bay Packers at Minnesota Vikings (+2.5) The Packers are riding high after shutting out the Seahawks and spoiling Russell...

How to Perform Univariate Analysis in R

Perform Univariate Analysis in R, In statistics, there are three different types of strategies for univariate data analysis. There are three types of analysis: univariate, bivariate, and multivariate. The term “univariate analysis” refers to a single-variable analysis. Because the prefix “uni” indicates “one,” you’ll remember this. Univariate analysis is a...