In a recent study published in Emergent Materials, researchers found common anti-inflammatory medications such as aspirin can help treat the most harmful outcomes of COVID-19. The study is from the University of Alberta. One author is Ayman El-Kadi. Most people infected with SARS-CoV-2 recover without serious symptoms. However, some patients...
A small but significant percentage of college athletes with COVID-19 develop myocarditis, a potentially dangerous inflammation of the heart muscle, that can only be seen on cardiac MRI, according to a study being presented today at the annual meeting of the Radiological Society of North America (RSNA). Myocarditis, which typically...
Pfizer is already quietly scrambling Friday as the COVID “variant of the moment” raises new questions about the efficacy of its vaccine (while the latest “data” shows Merck may have oversold its mulnupiravir drug as a “miracle cure” for the virus), it appears 26 new cases of the rare side effect known as myocarditis have been reported during the week ending Nov. 21.
This article was originally published on The Vegan CBD. To view the original article, click here. Cannabidiol’s ability to treat chronic health issues has become well known in the health and wellness space. Cannabidiol is useable for the seizures associated with epilepsy that standard medication cannot control. There is an array of pharmaceutical effects in CBD that can aid in relieving numerous health conditions. One of those conditions is inflammation, which occurs due to reasons such as fractures, injuries and so forth.
The first Virginia child dies of COVID-related MIS-C, a rare condition that causes organ inflammation
A Northern Virginia child has become the first in the state to die of multisystem inflammatory syndrome in children, a rare complication of COVID-19 that causes the body’s organs to become damaged. The Virginia Department of Health described the victim as a child between the ages of 10 and 19...
Excessive inflammation is the root of most illnesses. One may not see it, but it may be there, especially if you don’t work out regularly or eat healthily. Inflammation is how the body responds to stress, whether it’s environmental, emotional, physical, etc. When the body is continuously inflamed, the risk...
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DEAR DR. ROACH: The rims of my ears both get so sore I can’t even sleep on them. What can I do? — W.W. ANSWER: There are many causes for pain in the cartilage of the ear, including trauma and infection. However, when both ears are involved, it raises the concern for a rare but serious disease called relapsing polychondritis. This is an inflammatory and degenerative disease of unknown cause. It is most common in people of European ancestry and is often diagnosed between ages 40 and 60, but it can occur at any age. As the “relapsing” in its name suggests, symptoms can come and go.
It's well-documented that working out can improve one's mood, increase positivity, and reduce anxiety. This euphoric effect, often called a "runner's high," is usually chalked up to hormones released by the body called endorphins. Interestingly, however, scientists have speculated for quite some time that endocannabinoids, naturally-produced bodily "cannabis-like substances," are in actuality responsible for post-workout feelings of contentment.
Four studies have now shown that vaccination provides only moderate protection against the prolonged coronavirus in the event of a breakthrough infection. Tell those affected. * Names tagged with anonymity have been changed, age and canton are correct. since september he is Sebastian Wheeler was vaccinated twice with Pfizer. About...
Share on PinterestScientists have discovered that a form of vitamin D could help reduce lung inflammation in COVID-19. Zoonar RF/Getty ImagesA special form of Vitamin D — not found over the counter (OTC) — may be able to combat lung inflammation caused by immune cells, a new study suggests.The research shows vitamin D has a “switch-off” mechanism for inflammation, which could work in severe COVID-19.However, clinical trials are needed before vitamin D is adopted to treat COVID-19 or other respiratory diseases.The researchers warn against people taking more than the recommended amount of vitamin D in hopes of staving off COVID-19 infection.
Medical News Today
Physical activity may reduce the risk of Alzheimer’s disease and all-cause dementia and slow age-related cognitive decline. Aging and neurodegenerative conditions, such as Alzheimer’s disease, have associations with increased inflammation in the brain. Animal studies have shown that physical activity may lead to cognitive benefits by reducing the activation of...
Did you know that as many as six out of 10 Americans live with at least one chronic inflammatory disease?. Even though inflammation may be common, handling the symptoms is never a simple feat. Whether you’re dealing with arthritis inflammation, occasional aches, and pains, or other health conditions, this issue can be quite debilitating.
Hesperetin ameliorates hepatic oxidative stress and inflammationthe PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.
Jingda Li, Tianqi Wang, Panpan Liu, Fuyuan Yang, Xudong Wang, Weilong Zheng, Wenlong Sun. Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD. Hesperetin, a citrus flavonoid, is mainly found in citrus fruits (oranges, grapefruit, and lemons) and possesses multiple pharmacological properties, including anti-cancer, anti-Alzheimer and anti-diabetic effects. However, the anti-NAFLD effect and mechanisms of hesperetin remain unclear. In this study, we investigated the therapeutic effect of hesperetin against NAFLD and the underlying mechanism in vitro and in vivo. In oleic acid (OA)-induced HepG2 cells, hesperetin upregulated antioxidant levels (SOD/GPx/GR/GCLC/HO-1) by triggering the PI3 K/AKT-Nrf2 pathway, alleviating OA-induced reactive oxygen species (ROS) overproduction and hepatotoxicity. Furthermore, hesperetin suppressed NF-κB activation and reduced inflammatory cytokine secretion (TNF-α and IL-6). More importantly, we revealed that this anti-inflammatory effect is attributed to reduced ROS overproduction by the Nrf2 pathway, as pre-treatment with Nrf2 siRNA or an inhibitor of superoxide dismutase (SOD) or/and glutathione peroxidase (GPx) abolished hesperetin-induced NF-κB inactivation and reductions in inflammatory cytokine secretion. In a rat model of high-fat diet (HFD)-induced NAFLD, we confirmed that hesperetin relieved hepatic steatosis, oxidative stress, inflammatory cell infiltration and fibrosis. Moreover, hesperetin activated the PI3 K/AKT-Nrf2 pathway in the liver, increasing antioxidant expression and inhibiting NF-κB activation and inflammatory cytokine secretion. In summary, our results demonstrate that hesperetin ameliorates hepatic oxidative stress through the PI3 K/AKT-Nrf2 pathway andthat this antioxidative effect further suppresses NF-κB-mediated inflammation during NAFLD progression. Thus, our study suggests that hesperetin may be an effective dietary supplement for improving NAFLD by suppressing hepatic oxidative stress and inflammation.
BCL10 and MALT1 form ubiquitously expressed signalosomes that control immune and inflammatory pathways in many tissues. Pathological interplay between the immune system and keratinocytes is known to drive pathogenesis in psoriasis; however, the molecular and cellular functions of BCL10/MALT1 in the complex pathogenesis of psoriasis are not well defined. Kurgyis et al. engineered mouse models to specifically activate, inactivate, or attenuate BCL10/MALT1 signaling specifically in keratinocytes. They identified that BCL10 and MALT1 function to initiate and amplify keratinocyte responses to inflammatory cytokines and that constitutive activation of BCL10/MALT1 signaling in keratinocytes is sufficient to drive psoriasis. Furthermore, BCL10/MALT1 signaling is frequently altered in human psoriasis patients, suggesting that targeting the BCL10/MALT1 signalosome using MALT1 inhibitors may be a promising therapeutic approach to treat psoriasis.