The new Ghostbusters: Afterlife trailer teases a spooky cast reunion

The official trailer for Ghostbusters: Afterlife has arrived online – and Sony Pictures' reboot of its supernatural comedy series seems to be making all of the right noises ahead of its release. Dropping on Sony Pictures' social media channels on Tuesday, July 27, the new trailer showed off plenty of...

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer

Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple cancers to identify drugs that promote apoptosis in vivo. We therefore hypothesized that we could use DBP to identify drugs that would render cancers more sensitive to conventional chemotherapy. We found that targeted agents that increased priming of non-small cell lung cancer (NSCLC) tumor cells resulted in increased sensitivity to chemotherapy in vitro. To assess whether targeted agents that increase priming might enhance the efficacy of cytotoxic agents in vivo as well, we carried out an efficacy study in a PC9 xenograft mouse model. The BH3 mimetic navitoclax, which antagonizes BCL-xL, BCL-w, and BCL-2, consistently primed NSCLC tumors in vitro and in vivo. The BH3 mimetic venetoclax, which electively antagonizes BCL-2, did not. Combining navitoclax with etoposide significantly reduced tumor burden compared to either single agent, while adding venetoclax to etoposide had no effect on tumor burden. Next, we assessed priming of primary patient NSCLC tumor cells on drugs from a clinically relevant oncology combination screen (CROCS). Results confirmed for the first time the utility of BCL-xL inhibition by navitoclax in priming primary NSCLC tumor cells and identified combinations that primed further. This is a demonstration of the principle that DBP can be used as a functional precision medicine tool to rationally construct combination drug regimens that include BH3 mimetics in solid tumors like NSCLC.
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HBCU track & field stars in the Olympics, Part 4

An HBCU product, Dr. Leroy Walker, the first African-American to head the United State Olympic Committee (USOC) was in the spotlight as the 1996 Games came to Atlanta. The post HBCU track & field stars in the Olympics, Part 4 appeared first on HBCU Gameday.

Patriot All-America will expand to include top female amateurs in 2021

Amateur golf is steeped in tradition, and the calendar normally repeats itself from year to year. One of the final stops for the nation’s best college players is the Patriot All-America Invitational at the Wigwam Golf Resort in Litchfield Park, Arizona. Beginning in 2021, the “best” college players will mean...
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Mark Lomax, II

Mark Lomax, II, is a critically acclaimed drummer and composer. In 2019, he release his magnum opus, a 12-album work called 400: An Afrikan Epic. The project explores the story of African people through over 1,000 years of history – from the pre-colonial period, through the slave trade to the present and into the future.

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we demonstrate that never in mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to maintain its stability, causing PD-L1-targeted pancreatic cancer immunotherapy to have poor efficacy. We identify NEK2 as a prognostic factor in immunologically “hot” pancreatic cancer, involved in the onset and development of pancreatic tumors in an immune-dependent manner. NEK2 deficiency results in the suppression of PD-L1 expression and enhancement of lymphocyte infiltration. A NEK binding motif (F/LXXS/T) is identified in the glycosylation-rich region of PD-L1. NEK2 interacts with PD-L1, phosphorylating the T194/T210 residues and preventing ubiquitin-proteasome pathway-mediated degradation of PD-L1 in ER lumen. NEK2 inhibition thereby sensitizes PD-L1 blockade, synergically enhancing the anti-pancreatic cancer immune response. Together, the present study proposes a promising strategy for improving the effectiveness of pancreatic cancer immunotherapy.

The Firms Keeping Investors in the Know in Latin America

When the Covid-19 pandemic shut the world down last year, there was little time for anyone to adapt. But for the business of corporate access — which until last year connected investors and companies largely through travel and in-person events — the transition was especially stark. For Brazilian provider BTG...
Diseases & Treatmentstargetedonc.com

Rare Pediatric Disease Designation Granted to DAY101 for Low-Grade Glioma

DAY101, an investigational, oral, brain-penetrant, and highly selective type II pan-RAF kinase inhibitor for the treatment of rare, pediatric low-grade glioma, was granted a rare pediatric disease designation by the FDA. DAY101, an investigational, oral, brain-penetrant, and highly selective type II pan-RAF kinase inhibitor for the treatment of rare, pediatric...

Disabled children to be seen out of turn – presidential order

MOSCOW, July 27 (RAPSI) – President Vladimir Putin has signed a decree ordering shops, social and other institutions to see out handicapped children out of turn, according to the official website of legal information. The document amends the Order Concerning Additional Measures of State Support for Children with Disabilities of...

There’s ROI in Data Science

Data drives the investment world, but data science has seen greater wide-spread adoption in professional sports than it has in asset management. That’s not to suggest asset managers and their clients don’t covet data science and analysis, but rather that leveraging data science is sometimes viewed as clunky, expensive, and, well, not typically a part of the investment decision-making process.

Blue-Green Destructive Weather Rehearsal

JULY 27, 2021 – U.S. Marines and sailors with the 2nd Marine Logistics Group (MLG) and Expeditionary Strike Group (ESG) 2 took part in a rehearsal for the upcoming hurricane season which fulfilled Defense Support of Civil Authorities (DSCA) requirements at Naval Base Norfolk in Norfolk, Virginia, from July 19 to 23, 2021.
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Herons earn IWLCA academic accolades

NORTHBOROUGH, Mass. — The Intercollegiate Women's Lacrosse Coaches Association announced its 2020-21 academic award winners today. William Smith College was one of 285 schools across NCAA Divisions I, II and III, and NAIA to merit the IWLCA Academic Honor Squad award. In addition, 11 Herons earned a spot on the IWLCA Division III Academic Honor Roll.