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Cancercuretoday.com

Exploring Potential Treatment Options for Rare Cancers

Read more about the current research for the disease, as well as how these advances impact the patients diagnosed with it. AN ESTIMATED 1 IN 30,000 people receive a diagnosis of von Hippel-Lindau (VHL) disease, and 10% of them do not have a family history, according to the American Society of Clinical Oncology (ASCO).
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CancerNature.com

Epigenetic scars of CD8 T cell exhaustion persist after cure of chronic infection in humans

T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not known whether that chromatin landscape is fixed or plastic following the resolution of a chronic infection. Here we show that the epigenetic state of exhaustion is largely irreversible, even after curative therapy. Analysis of chromatin accessibility in HCV- and HIV-specific responses identifies a core epigenetic program of exhaustion in CD8+ T cells, which undergoes only limited remodeling before and after resolution of infection. Moreover, canonical features of exhaustion, including super-enhancers near the genes TOX and HIF1A, remain ‘epigenetically scarred.’ T cell exhaustion is therefore a conserved epigenetic state that becomes fixed and persists independent of chronic antigen stimulation and inflammation. Therapeutic efforts to reverse T cell exhaustion may require new approaches that increase the epigenetic plasticity of exhausted T cells.
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