Philippines Arrests Alleged Mastermind of Forex Fraud Based Eastern Europe

An Israeli who was the alleged mastermind of a Forex scam scheme was arrested in the Philippines one year after fleeing Bulgaria. According to Calcalist, Kfir Levy operated a fraud network in Eastern Europe running forex and binary options scams, allegedly deceiving thousands of investors in the region. The authorities...
Picture for Philippines Arrests Alleged Mastermind of Forex Fraud Based Eastern Europe

Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Optineurin (OPTN) has important functions in diverse biological processes and diseases, but its effect on dendritic cell (DC) differentiation and functionality remains elusive. Here we show that OPTN is upregulated in human and mouse DC maturation, and that deletion of Optn in mice via CD11c-Cre attenuates DC maturation and impairs the priming of CD4+ T cells, thus ameliorating autoimmune symptoms such as experimental autoimmune encephalomyelitis (EAE). Mechanistically, OPTN binds to the JH1 domain of JAK2 and inhibits JAK2 dimerization and phosphorylation, thereby preventing JAK2-STAT3 interaction and inhibiting STAT3 phosphorylation to suppress downstream transcription of IL-10. Without such a negative regulation, Optn-deficient DCs eventually induce an IL-10/JAK2/STAT3/IL-10 positive feedback loop to suppress DC maturation. Finally, the natural product, Saikosaponin D, is identified as an OPTN inhibitor, effectively inhibiting the immune-stimulatory function of DCs and the disease progression of EAE in mice. Our findings thus highlight a pivotal function of OPTN for the regulation of DC functions and autoimmune disorders.
Picture for Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

EU court fines Poland 1 mln euros per day in rule of law row

WARSAW, Oct 27 (Reuters) - Poland must pay 1 million euros ($1.16 million) a day for maintaining a disciplinary chamber for judges, the European Union's top court said on Wednesday, in the latest episode of a clash over the rule of law with implications for Warsaw's future ties with the bloc.
Picture for EU court fines Poland 1 mln euros per day in rule of law row
Washington Post

The strange backdrop to the G-20: a Roman neighborhood built as a fascist showpiece

ROME — In the Roman neighborhood known as EUR, all the classic telltales of Rome drop away. Gone are the cobblestone roads, the antiquities, the worn palazzi dappled like watercolors. What you get instead are broad boulevards and imposing white buildings, plus a man-made lake. Everything is orderly, planned. Look in the right direction, and you’ll even see a sculpture heroically depicting the planner: Benito Mussolini.

S&P 500, Dow Jones Outlook: Retail Traders Continue Selling, Will Prices Rise?

Since the majority of them are net-short, prices may keep climbing. Shooting Star candlesticks in them hint to watch for follow-through. Looking at IG Client Sentiment (IGCS), retail traders are continuing to sell the major benchmark stock indices on Wall Street such as the S&P 500 and Dow Jones. IGCS can at times be a contrarian indicator. If investors keep selling into recent price action, these indices could continue rising. To learn more about how can you use this tool in your own strategy, check out the recording of my webinar above.

EUR/GBP Standstill at 0.8420 with ECB Interest Rate Decision on Tap

On October 28, the ECB meeting will conclude several hours after the BOJ meeting. The rising number of coronavirus cases in the eastern region of Europe is due to the low rate of inoculation. EUR/GBP is trading at 0.8429 level, having bounced off above the support level of 0.8400. The...

United Plugins Spooky Bundle: 4 plugins on sale at up to 80% OFF

Plugin Boutique has launched a promotion on the Spooky Bundle by United Plugins, offering discounts of up to 80% off on a collection of 4 audio plugins. Halloween time calls for spooky and weird sounds. And you may well be ready to create them using the effects in our time-limited Spooky Bundle.

EUR/USD Rate Consolidates with ECB Interest Rate Decision on Tap

EUR/USD consolidate after trading to a fresh monthly high (1.1669) during the previous week, but the European Central Bank (ECB) interest rate decision may sway the near-term outlook for the exchange rate if the Governing Council adjusts the forward guidance for monetary policy. EUR/USD Rate Consolidates with ECB Interest Rate...

Daily Asia-London Sessions Watchlist: EUR/AUD

Top tier Aussie economic data is right around the corner, making the price action in EUR/AUD one to watch for potential opportunities to play the downtrend. Before moving on, ICYMI, today’s Daily U.S. Session Watchlist looked at the uptrend in USD/JPY ahead of U.S. data, so be sure to check that out to see if there is still a potential play!

EUR/GBP Likely to be Choppy as BOE-ECB Risks Unfold

EUR/GBP finds support as traders prepare for ECB and BOE meetings. GBP hawkish expectations leave ample room for disappointment. EUR/GBP continues to trade with a bearish inclination as the pound remains supported by expectations that the Bank of England will need to step up its efforts to reduce monetary stimulus in its meeting next week. The pair has been struggling for the last month, having come off almost 3% since hitting a new two-month high on September 29th. It seemed like buyers had managed to find support around 0.8420 last week but comments from BOE Governor Bailey about the need to act to contain inflation have only added more fuel to the recent GBP bullishness.

Alfacash Store improved SEPA transfers along with BCB Payments

On Alfacash Store, the users can already buy and sell over 19 cryptocurrencies against euros (EUR). This is the fastest and safest way to trade digital currencies in the European Union, and we’re constantly improving our services. Now, we’re partnering with BCB payments to offer additional options for SEPA transfers.

GBP EUR Surges to New Yearly Highs Ahead of Budget

The GBP EUR exchange rate was higher by 0.28% on Tuesday with the pair touching the 1.1900 level. A recent slowdown in the European economy is seeing rate hike bets in the pound sterling. The UK will also see the Autumn budget delivered by Rishi Sunak today. UK virus cases have bene predicted to fall in coming weeks and that has also supported the pair.

The Asian USD High Yield Credit Bond Market

Following our Asian USD credit primer published last month, we further probe the high yield segment of the Asian (ex-Japan) USD credit bond market. We explore the segment's rapid growth, sector exposures, spreads, and correlations with other asset classes. We also discuss how Chinese issuers play a significant role in this segment. In this article, we will be using relevant IHS Markit iBoxx fixed income benchmarks to represent the major high yield bond markets.

Daily U.S. Session Watchlist: EUR/GBP

I’ve got this simple break-and-retest setup on the short-term chart of EURGBP. Before moving on, ICYMI, today’s Asia-London session watchlist looked at a bullish divergence and pullback on EUR/AUD ahead of Australia’s quarterly CPI. Be sure to check out if it’s still a valid play!. And now for the headlines...
Business Insider

Edaa and Euroclear to launch new post trade link in Saudi Arabia

The link, which is expected to be launched in March 2022, will provide an additional channel for international investors to access the sukuk and bond market within the Saudi Exchange, the largest in the Gulf Cooperation Council (GCC) area among the largest stock exchanges globally and one of the top three largest emerging market exchanges with a market capitalization of more than US$2.5 trillion.

Australian dollar firms into inflation

The AUD had another strong night on today’s inflation print. A big yawn for me:. Base metals too on signs China is lifting metals processing output:. But the Treasury curve looks more and more like the curve flattening is here to stay:. Stocks held at record highs:. Westpac has the...