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#Elizabeth R

BioMed Central

ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens

Elizabeth R. Hutton1, Christopher R. Vakoc2 & Adam Siepel ORCID: orcid.org/0000-0002-3557-72191,2. Genome Biology volume 22, Article number: 278 (2021) Cite this article. High-throughput CRISPR-Cas9 knockout screens are widely used to evaluate gene essentiality in cancer research. Here we introduce a probabilistic modeling framework, Analysis of CRISPR-based Essentiality (ACE), that accounts for multiple sources of variation in CRISPR-Cas9 screens and enables new statistical tests for essentiality. We show using simulations that ACE is effective at predicting both absolute and differential essentiality. When applied to publicly available data, ACE identifies known and novel candidates for genotype-specific essentiality, including RNA m6-A methyltransferases that exhibit enhanced essentiality in the presence of inactivating TP53 mutations. ACE provides a robust framework for identifying genes responsive to subtype-specific therapeutic targeting.
SCIENCE
seillinoisnews.com

Two nursing home administrator licenses are set to lapse in ZIP Code 62917 during Q4

At least two nursing home administrator licenses are set to lapse in ZIP Code 62917 during the fourth quarter, according to the Illinois Department of Financial and Professional Regulation (IDFPR). Licenses will lapse unless they are renewed before their expiration date. IDFPR comprises several agencies, bureaus and commissions that influence...
POLITICS
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cumberland.crimewatchpa.com

35 780-113(a)(32) Possession of Drug Paraphernalia

Yeingst, Elizabeth R - 35 780-113(a)(32) Possession of Drug Paraphernalia. On September 17, 2021, the Middlesex Township Police Department went to a local motel to conduct a welfare check on Elizabeth Yeingst. Upon arrival officer made contact with Yeingst and while speaking with Yeingst the officer noticed drug paraphernalia in plain view inside the motel room. Yeingst...
MIDDLESEX, PA
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TRENDING TOPICS
goodhousekeeping.com

How the Queen paid tribute to victims of 9/11

Saturday marked the 20th anniversary of 9/11 and the Queen paid tribute to the thousands of people who lost their lives. Releasing a heartfelt statement, the Queen reflected on the tragic events and revealed that all of those affected were in her and her family’s thoughts and prayers. This content...
U.K.
Fauquier Times-Democrat

In-person absentee voting for statewide election begins Friday, Sept. 17

Any registered voter in Fauquier County may cast an in-person absentee ballot for the 2021 general election at the main registrar’s office in Warrenton beginning Friday, Sept. 17. Official voting resources. Virginia Department of Elections: vote.elections.virginia.gov. Fauquier County Office of the General Registrar: 540-422-8290. Candidates for governor, lieutenant governor and...
WARRENTON, VA
The State-Journal

Property transfers (August 2021)

The following property transfers were filed at the Franklin County Courthouse in August:. • Earl A. and Vicki R. Goode to Kenneth A. and Jessica M. Fairchild, 2833 Leestown Road, $157,000. • David and Andy Oechsli to Matthew L. Gilbert, 109 Thomas St., $172,000. • Wells Fargo Bank NA to...
FRANKFORT, KY
townandcountrymag.com

Queen Elizabeth, Kate Middleton, and Other Royals Congratulate Emma Raducanu on U.S. Open Victory

On Saturday, British teenager Emma Raducanu stunned tennis fans around the world, as she won the U.S. Open. Previously ranked 150th in the world, 18-year-old Raducanu beat Canadian Leylah Fernandez in the women's singles final, winning the U.S. Open without dropping a single set. In honor of Raducanu's outstanding performance, the British royal family sent a slew of congratulatory messages to the teenage tennis star.
TENNIS
leelanaunews.com

Real estate transfers recorded in county

September 2, 2021 Phyllis A. Konold to herself, Lot 17, Pierce Stocking Development No. 1 in Glen Arbor Township. Kenneth Hornyak and Kriste R. Kerlin-Hornyak to themselves, Lots 3 and 4, Section 21 in Elmwood Township. Elizabeth R. Brien, Successor Trustee of Theola K. Hemphill Irrevocable Trust to Patrick M. and Cheryl L. Conway, Unit 7, Northwood Glen Condominium in […]
GLEN ARBOR, MI
Cosmopolitan

Emma Raducanu wins US Open Grand Slam title and takes home £1.8million

Emma Raducanu has secured her first US Open title at just 18 years old. Not only has she secured a title, but she's also secured £1.8million – that kind of money is the stuff of dreams, right? Especially when all you wanted was some new earphones. Quoted by the Daily...
TENNIS
purewow.com

Queen Elizabeth Pens a Personal Congratulations to US Open Champion Emma Raducanu on Instagram

It's been a pretty exciting week for tennis player Emma Raducanu. The 18-year-old Brit was just crowned the US Open champion, becoming the youngest female Grand Slam champion since 17-year-old Maria Sharapova won the same title at Wimbledon in 2004. According to ESPN, Raducanu is also “the first woman to win the US Open title without dropping a set since Serena Williams in 2014.” The last British woman to win a Grand Slam singles trophy was Virginia Wade all the way back in 1977.
TENNIS
GoodtoKnow

Emma Raducanu reveals what she’ll be doing with Queen’s heartfelt letter

We earn a commission for products purchased through some links in this article. Tennis star Emma Raducanu has opened up following her historic US Open win to reveal what she might do with the Queen’s letter of congratulations. The Queen has sent the new US Open Champion Emma Raducanu a...
TENNIS
Hello Magazine

Celebrities pay heartbreaking tributes on 9/11: from Kate Hudson to Catherine Zeta-Jones

Celebrities have paid tribute to the nearly 3,000 lives lost on September 11 2001 as the world mourns the 20th anniversary. The attacks were a series of four coordinated terrorist attacks and it remains the deadliest terrorist attack in human history, with 2,977 innocent people dying including 340 firefighters and 72 police officers, and over 25,000 injured.
CELEBRITIES
purewow.com

Queen Elizabeth II Wrote a Personal Message to the U.S. on the 20th Anniversary of 9/11

As the United States mourns the lives of those lost twenty years ago on September 11, a message of love was just sent across the pond. Queen Elizabeth II turned to Instagram to send a personal letter to President Biden and the rest of the nation (which she signed once again with “Elizabeth R”). The note was shared to the royal family Instagram account, where they said, “The Queen’s message to the President of the United States on the 20th anniversary of the attacks on 11th September 2001.”
U.S. POLITICS
royal.uk

The Queen's message to Emma Raducanu following her US Open win

It is a remarkable achievement at such a young age, and is testament to your hard work and dedication. I send my congratulations to you on your success in winning the United States Open Tennis Championships. It is a remarkable achievement at such a young age, and is testament to your hard work and dedication. I have no doubt your outstanding performance, and that of your opponent Leylah Fernandez, will inspire the next generation of tennis players. I send my warmest good wishes to you and your many supporters.
TENNIS
kendallcountytimes.com

31 clinical professional counselor licenses are set to lapse in ZIP Code 60543 during 2021

At least 31 clinical professional counselor licenses are set to lapse in ZIP Code 60543 during 2021, according to the Illinois Department of Financial and Professional Regulation (IDFPR). Licenses will lapse unless they are renewed before their expiration date. IDFPR comprises several agencies, bureaus and commissions that influence business growth...
HEALTH
StreetInsider.com

Form 4 SONOCO PRODUCTS CO For: Sep 10 Filed by: Florence John M

Get instant alerts when news breaks on your stocks. Claim your 1-week free trial to StreetInsider Premium here. Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned. Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned. 1. Each share of Dividend equivalents on Restricted Stock units...
ECONOMY
South Coast Today

Property Transfers: How much are homes selling for in your neighborhood?

Stephen R. and Brooke W. Riley to Zacharia L. Culver. 16 Roosevelt St $285,000. Kalyn Miller to Lawrence W. and Lynne M. Fernandes. Wilmington T NA Tr to Joshua T. Sevigny and Kathryn F. Braley. 29 Slocum St $375,000. Jessica Vermette to Andrew Benson. BOURNE. 112 Barlows Landing Rd $479,000.
ACUSHNET, MA
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