You can turn off enemy glow in Diablo 4
Something I pointed out when we discussed Diablo 4's figurative and literal 'darkness' back in 2019 is that, although you can't see it in the official gameplay trailers, holding the cursor over an enemy highlights them with a red glow, and hitting them makes them glow even brighter with whitish light. That's a pretty normal videogame thing, but it does somewhat undermine the sense of being swallowed by darkness. Good news if you're not into it: You can turn it off.