CreatorsPublishersAdvertisers

#Cry

thewordisbond.com

GeeJay reflect deeply on “Mama, it’s OK to Cry”

UK duo share Geejay new heartfelt single “Mama, it’s OK to Cry” which dives into personal loss and pain. It was inspired by the changing relationship dynamics between vocalist Gee and her mother after her father died in 2017. Bolstered by a somber and highly soulful backdrop, Gee details how she had to stand strong and hold down the fort for her grieving mother.
MUSIC
Picture for GeeJay reflect deeply on “Mama, it’s OK to Cry”
Rotowire

FanDuel Fantasy Soccer: Saturday EPL Targets

MATCHES (ET) Mohamed Salah, LIV v. CRY ($23): There's a couple factors at play here besides Salah being an incredible goal scorer in a favorable matchup. He's scored in four of five matches this season, including Sunday's win over Leeds United and Wednesday's Champions League win over AC Milan. He's in great form and has the highest goal-scoring odds on the slate while playing for the second-biggest favorite. The one concern is that this will be his third match in seven days, though Liverpool are dealing with injuries to Divock Origi and Roberto Firmino, which should keep him in a prominent role. If Salah is too expensive, Sadio Mane ($21) has looked sharp to begin the season and will benefit from coming off the bench Wednesday. He took 10 (!) shots and scored a goal against Leeds United and will have another good opportunity against Palace. Last, but not least, Diogo Jota ($20) is the cheapest of Liverpool's attack and has finished with at least 23 points in his three Premier League starts.
PREMIER LEAGUE
Picture for FanDuel Fantasy Soccer: Saturday EPL Targets
TRENDING TOPICS
britannica.com

Faith Hill

Faith Hill, originally Audrey Faith Perry, (born September 21, 1967, Jackson, Mississippi, U.S.), American country music singer known for her commercial success on both the country and pop music charts. Hill grew up in Star, Mississippi, where she began singing at an early age. Her first public performance was at...
MUSIC
iheartintelligence.com

YouTuber caught forcing her 9-year-old son to CRY over their dying dog for a thumbnail

A YouTuber is under fire for forcing her 9-year-old son to “act like he’s crying” over their dying dog while trying to get a thumbnail for her video. Jordan Cheyenne, 30, a California-based ex-YouTuber has received a wave of criticism from her subscribers. In a now-deleted video titled “We are heartbroken,” she apparently forgot to edit out the part where she’s actually coaching her devastated 9-year-old son to cry for the thumbnail.
BEHIND VIRAL VIDEOS
Nature.com

Structure-based design and classifications of small molecules regulating the circadian rhythm period

Circadian rhythm is an important mechanism that controls behavior and biochemical events based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is associated with different diseases such as cancer, mood disorders, and familial delayed phase sleep disorder. Therefore, drug discovery studies have been initiated using high throughput screening. Recently the crystal structures of core clock proteins (CLOCK/BMAL1, Cryptochromes (CRY), Periods), responsible for generating circadian rhythm, have been solved. Availability of structures makes amenable core clock proteins to design molecules regulating their activity by using in silico approaches. In addition to that, the implementation of classification features of molecules based on their toxicity and activity will improve the accuracy of the drug discovery process. Here, we identified 171 molecules that target functional domains of a core clock protein, CRY1, using structure-based drug design methods. We experimentally determined that 115 molecules were nontoxic, and 21 molecules significantly lengthened the period of circadian rhythm in U2OS cells. We then performed a machine learning study to classify these molecules for identifying features that make them toxic and lengthen the circadian period. Decision tree classifiers (DTC) identified 13 molecular descriptors, which predict the toxicity of molecules with a mean accuracy of 79.53% using tenfold cross-validation. Gradient boosting classifiers (XGBC) identified 10 molecular descriptors that predict and increase in the circadian period length with a mean accuracy of 86.56% with tenfold cross-validation. Our results suggested that these features can be used in QSAR studies to design novel nontoxic molecules that exhibit period lengthening activity.
SCIENCE
Rotowire

DraftKings Fantasy Soccer: Saturday EPL Picks

MATCHES (EDT) Nicolas Pepe, ARS at BUR ($8,700): Manchester City and Liverpool are big favorites and will be popular targets, but neither team really has any cash plays at forward. Meanwhile, Pepe scored a whopping 23 floor points last weekend. He's been taking a majority of Arsenal's set pieces and has played the full 90 minutes in all three of his starts this season. The matchup away to Burnley is above average, and Pepe brings plenty of goal/assist upside to go along with his substantial floor. Tournament options in this range include Gabriel Jesus ($8,500) and Riyad Mahrez ($8,400), as Manchester City have an implied goal total north of 2.5 for their home matchup against Southampton. The Liverpool options are more expensive for their equally good matchup at home to Crystal Palace, but Diogo Jota ($8,300) is still affordable.
SOCCER
lyricallemonade.com

isolation – [Demxntia] ft. [ITSOKTOCRY]

Not too long ago, I was put onto Demxntia’s very versatile discography of music, and even though I still need to do more digging to familiarize myself with the rest of his music, let’s just say that I haven’t heard a miss yet, and that gets me excited for the future of his career. Beyond this, I’ve also come to learn in a short period of time that he’s an all-out workhorse, never taking a minute off but rather grinding day in and day out to deliver a plethora of songs that are all even more creative than the last, so there’s never any shortage of output from the Florida talent.
MUSIC
ideahuntr.com

Crystal Palace 1-0 Spurs live in Premier League, watch live stream

Premier League LIVE streaming: Can Tottenham maintain winning streak to stay at the top of the table as they travel to face Crystal Palace? Crystal Palace vs Spurs live stream, follow for live updates- Crystal Palace has yet to win its first game in the Premier League 2021/22 season. However, they came back from behind in their last match against West Ham to settle for a point in the 2-2 draw. Follow all the updates of CRY vs TOT live on insdesport.co.
PREMIER LEAGUE
datadriveninvestor.com

Fantasy EPL GW3 Recap and GW4 Algo Recommendations

If this is the first time you land on one of our Fantasy EPL Blogs, you might want to check out some of our original blogs in my Medium archives to get familiar with our overall approach and the improvements we’ve made to the captain/team recommender algorithm over time. The...
SPORTS
Nature.com

Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells

Nucleotide excision repair (NER) and cell cycle checkpoints impact the ability of the anti-cancer drug cisplatin to inhibit cell proliferation and induce cell death. Genetic studies have shown that both NER and cell cycle progression are impacted by the circadian clock, which has emerged as a novel pharmacological target for the treatment of various disease states. In this study, cultured human cell lines were treated with combinations of cisplatin and the circadian clock modulating compounds KS15 and SR8278, which enhance circadian clock transcriptional output by inhibiting the activities of the cryptochrome and REV-ERB proteins, respectively. Treatment of cells with KS15 and SR8278 protected cells against the anti-proliferative effects of cisplatin and increased the expression of NER factor XPA and cell cycle regulators Wee1 and p21 at the mRNA and protein level. Correlated with these molecular changes, KS15 and SR8278 treatment resulted in fewer unrepaired cisplatin–DNA adducts in genomic DNA and a higher fraction of cells in the G1 phase of the cell cycle. Thus, the use of pharmacological agents targeting the circadian clock could be a novel approach to modulate the responses of normal and cancer cells to cisplatin chemotherapy regimens.
CANCER
BBC

Dylan Rich: Young footballer who died was much-loved, says head

A young footballer who died after suffering a suspected cardiac arrest during a match was "much-loved" and "talented", his head teacher has said. Dylan Rich collapsed during an FA Youth Cup game between West Bridgford Colts and Boston United in Nottinghamshire. He is then thought to have had a second...
SPORTS

The Top 10 Best Movies Filmed In Boston

While I thought it would be California where most movies are filmed, it's actually New York City! However, some of the greatest movies ever were filmed in Boston. In no particular order, here are my top ten movies filmed in Boston, Massachusetts. 1. "MYSTIC RIVER" (2003) KEVIN BACON, SEAN PENN...
BOSTON, MA
greenmedinfo.com

Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF‑κB signaling pathway.

Yijiao Yang, Ling Yang, Cao Qi, Guohua Hu, Longhui Wang, Zhuojun Sun, Xiaorong Ni. Cryptotanshinone (CRY) has been demonstrated to reverse reproductive disorders. However, whether CRY is effective in the treatment of polycystic ovary syndrome (PCOS) remains unknown. The aim of the present study was to evaluate the therapeutic potential of CRY in PCOS. A rat model of PCOS was established by daily injection of human chorionic gonadotropin and insulin for 22 days. Total body weight and ovarian weight, as well as the levels of luteinizing hormone (LH) and the LH to follicle‑stimulating hormone (FSH) ratio (LH/FSH) significantly increased in rats with PCOS, compared with controls. Moreover, the levels of testosterone (T), tumor necrosis factor (TNF)‑α and high‑mobility group box 1 protein (HMGB1) also increased. However, CRY treatment attenuated the increase in body weight, ovarian weight, LH, LH/FSH ratio, T, TNF‑α and HMGB1 levels, compared with the PCOS group. Treatment with CRY also reduced NF‑κB/p65, HMGB1 and toll‑like receptor (TLR)4 mRNA and protein expression levels in the ovarian tissue and granulosa cells, both in vitro and in vivo. Thus, CRY significantly mitigated the changes in body weight, ovary weight, hormone levels and inflammatory factor levels observed in rats with PCOS. Thus, CRY protects against PCOS‑induced damage of ovarian tissue, possibly through a regulatory pathway involving HMGB1, TLR4 and NF‑κB.
SCIENCE
analystratings.com

The SVP & GC of Cryolife (NYSE: CRY) is Selling Shares

In addition to Jean Holloway, 2 other CRY executives reported Sell trades in the last month. Following Jean Holloway’s last CRY Sell transaction on March 11, 2021, the stock climbed by 1.4%. See today’s analyst top recommended stocks >>. Based on Cryolife’s latest earnings report for the quarter ending June...
STOCKS
gamingbolt.com

10 Reasons to be Excited About Far Cry 6

Far Cry’s brand of open world gameplay mixed with focused storytelling and emergent action has turned the series into one of Ubisoft’s biggest properties over the years, and with Far Cry 6, Ubisoft seems to be ramping things up in more ways than one. After nearly five hours with the game, we can confidently say that we’re excited about how it’s shaping up. Here, we’re going to talk about our biggest takeaways from the opening few hours of Far Cry 6.
VIDEO GAMES
YOU MAY ALSO LIKE