The leadership ranks at UnitedHealth Group's Optum are filled with former healthcare executives, longtime UnitedHealth veterans and leaders from acquired companies. John Prince. President and COO of Optum. Mr. Prince was selected for his role in April, where he is responsible for guiding Optum's enterprise performance, financial services, global operations and digital innovation. Prior to his role, he was the CEO of OptumRx. Mr. Prince has worked in various roles with UnitedHealth since 2005.