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New Research Shows How Ketamine Acts As “Switch” in the Brain
According to a new study by researchers at Penn Medicine, ketamine, which is well-known as an anesthetic and is becoming increasingly popular as an antidepressant, dramatically reorganizes activity in the brain, almost as if a switch were turned on. The study, published in Nature Neuroscience, found that after administering ketamine, there were drastic changes in the patterns of neuronal activity in the cerebral cortex of animal models. Neurons that were usually active were silenced, while others that were usually inactive suddenly became active.