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Cavs: Grading the Jarrett Allen signing on three levels

The Cleveland Cavaliers made their big splash of the offseason in the NBA Draft, taking big man Evan Mobley with the No. 3 overall pick. Whatever the Cavs end up doing in free agency is secondary to taking what they hope and expect is the future star of the franchise.
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Red Wings: Predicting the Contracts of the Remaining RFAs

There’s still some work to do for Detroit Red Wings general manager Steve Yzerman after he inked Tyler Bertuzzi to a two-year deal last Saturday. With both Adam Erne and Jakub Vrana headed to arbitration (though it’s very likely a deal gets done before it sees an arbitrator), Filip Hronek, Givani Smith, and Chase Pearson join the aforementioned two as the final restricted free agents still seeking a contract.
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Islanders: Looking At Past Arbitration Cases

It’s been announced that Adam Pelech has filed for arbitration. As our very own Brian Weinberger laid out earlier this week, the Islanders and Adam Pelech would have to present to an arbitrator their case on what the next contract should be. Arbitration is an ugly, ugly process and you...
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Gem gene sparkles as ischemic stroke drug discovery target

The collective findings of a new multicenter Japanese study have demonstrated for the first time that expression of the gene Gem via the activity-dependent transcription factor, neuronal PAS domain protein 4 (Npas4), promotes neuroprotection in the injured brain following ischemic stroke. Importantly, Gem was also shown to be induced in...
NHLThe Hockey Writers

NHL Rumors: Oilers, Rangers, Blue Jackets, Canadiens, More

In today’s NHL rumors, Elliotte Friedman offers a number of updates on some of the lingering stories coming out of NHL free agency. There is talk the Edmonton Oilers and Darnell Nurse are close on a long-term extension, the New York Rangers might be nearing a deal with Igor Shesterkin and the Columbus Blue Jackets are trying to trade Max Domi. Finally, could the Montreal Canadiens try to trade for Vince Dunn and the Rangers for Jack Eichel?

Flames, Candiens, Wild, Sharks interested in Christian Dvorak

With the Arizona Coyotes looking to do a full rebuild it is looking like Christian Dvorak is available for trade. Elliotte Friedman is reporting the San Jose Sharks, Calgary Flames, Minnesota Wild, Montreal Canadiens, and the New York Rangers as the teams with the most interest. Friedman went on to...
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Islanders Casey Cizikas signed to 6 year contract (Rumor)

Lou Lamoriello is taking the time he has to dot every “i” and cross every “t” before officially announcing anything that the New York Islanders have done this offseason. It’s all quiet on the Islanders UFA front which leads many to believe they’re all signed but the paperwork hasn’t been...

Jets Mailbag: How much will re-signing Andrew Copp, Neal Pionk cost?

WINNIPEG — The roster projections for the Winnipeg Jets look significantly different than they did 10 days ago and a good chunk of the off-season to-do list has already been taken care of. While Jets general manager Kevin Cheveldayoff didn’t dive into the deep end of the free agent frenzy,...
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Islanders: Why Signing Ryan Murray Makes Sense

At this point, you’re probably well aware of the lack of left-handed defensemen available. With the Islanders trading away Nick Leddy, the team will have to find someone who can play top-four minutes on the left to fill that role. Internally, Andy Greene’s not going to be able to do...

Lentiviral and AAV-mediated expression of palivizumab offer protection against Respiratory Syncytial Virus infection

Respiratory syncytial virus (RSV) infection is a common cause of hospitalisation in infants and the elderly. Palivizumab prophylaxis is the only approved treatment modality but is costly and only offered to select vulnerable populations. Here, we investigated gene delivery approaches via recombinant adeno-associated virus (rAAV2/8) and simian immunodeficiency virus (rSIV.F/HN) vectors to achieve sustained in vivo production of palivizumab in a murine model. Delivery of palivizumab-expressing vectors 28 days prior to RSV challenge resulted in complete protection from RSV-induced weight loss. This approach offers prophylaxis against RSV infection, allowing for wider use and reduction in treatment costs in vulnerable populations.

SURPRISE: Chicago Bulls Ink Alex Caruso to Four-year, $37M Deal

Arutras Karnisovas knows how to keep things close to the vest, and he reminded us of this a couple of hours into free agency. The Chicago Bulls have signed Lakers guard Alex Caruso to a four-year deal with $37 million. Uh, yeah, to say I did not see this coming...
NHLThe Hockey Writers

NHL Rumors: Sharks, Blackhawks, Rangers, Canucks, More

In today’s NHL rumors rundown, the San Jose Sharks will cooperate with an NHL investigation of forward Evander Kane who is being accused to gambling on NHL hockey games, specially ones he was playing in. Meanwhile, goaltender Marc-Andre Fleury has informed the Chicago Blackhawks he’ll report next season. Did the New York Rangers make a trade offer for Jack Eichel? Finally, are the Vancouver Canucks worried about an offer sheet for Elias Pettersson?
Butte, MTMontana Standard

'The best decision I ever made'

James Joseph “Jim” Duddy looked a lot like a lodgepole pine when he first faced off with notoriously pitiless Leatherneck drill instructors in San Diego. Duddy, a Butte native, was 6 feet, 5 inches tall and weighed just 160 pounds. “I was a stick,” he said. Duddy was 21 years...

Casey Cizikas Deal Done? One NHL Insider Thinks So

Is a deal for Casey Cizikas already Done with the New York Islanders? Sportsnet’s Elliotte Friedman appeared to think it was on the latest edition of his 31 Thoughts podcast. The NHL insider speculated that a deal had been completed by the two sides and that it was a long-term...

Researchers Film Human Viruses in Liquid Droplets at Near-atomic Detail

A pond in summer can reveal more about a fish than a pond in winter. The fish living in icy conditions might remain still enough to study its scales, but to understand how the fish swims and behaves, it needs to freely move in three dimensions. The same holds true for analyzing how biological items, such as viruses, move in the human body, according to a research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, who has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.
NHLLA Kings Insider

LA Kings sign forward Brayden Burke to one-year, two-way contract, $750K AAV

The LA Kings have signed forward Brayden Burke to a one-year, two-way contract extension with an average annual value (AAV) of $750,000 at the NHL level. Burke, 24, was acquired via trade from the Arizona Coyotes on Day 2 of the NHL Draft. He recorded 14 points (1-13=14) in 28 games last season with the Tucson Roadrunners (AHL). He skated in three full seasons with the Roadrunners, posting 99 points (35-64=99) in 146 games. In 2019-20, the Edmonton, Alberta native paced all Tucson skaters with 52 points (21-31=52) and 21 goals in 51 games, as he was selected to represent the Pacific Division at the 2020 AHL All-Star Classic, hosted by the Ontario Reign.