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Twins’ Carlos Correa plans, with a Xander Bogaerts twist

The Minnesota Twins are “getting creative” with their free agency offers to keep shortstop Carlos Correa in Minneapolis, according to a Thursday morning report from FanNation. Minnesota Star-Tribune beat writer La Velle E. Neal III said the team is experimenting with different lengths and total money offered per year. It could take a free agency […] The post Twins’ Carlos Correa plans, with a Xander Bogaerts twist appeared first on ClutchPoints.
MINNEAPOLIS, MN
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bleachernation.com

Obsessive Top Shortstop Watch: Twins with Multiple Correa Offers, Cubs Won’t Set the Market, Phillies Lurking, More

Best Buy should’ve done sales on top shortstops today, dang it. Anyway, some of the latest from the rumor mill about the top free agent shortstops, specifically …. Out of Minnesota, the efforts to keep Carlos Correa on the Twins are very real. They may or may not likely their chances, ultimately, but they are trying to get creative:
CHICAGO, IL
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montrealhockeynow.com

Top-3 Montreal Canadiens Players At Risk Of Losing Their Spot

With the 2022-23 season in full swing, the Montreal Canadiens have enjoyed their fair share of pleasant surprises throughout the roster. Samuel Montembeault has exceeded all expectations, Cole Caufield has become one of the league’s best 5v5 goal scorers, Nick Suzuki has evolved into a dominant presence at both ends of the ice, and the four rookie defencemen have navigated the difficult transition to the NHL with aplomb.
ajmc.com

Current Research and Logistical Considerations for Gene Therapy in Hemophilia

A recent review poses gene therapy as a novel treatment option with potential to reduce health care disparities globally. The treatment paradigm for hemophilia differs between countries due to varied socioeconomic environments, and a recent review poses gene therapy as a novel treatment option with potential to reduce disparities. The...
ophthalmologytimes.com

Gene therapy trial highlights RPGR-associated X-linked RP

The therapy offers improved retinal sensitivity, visual function, as well as improvements in mobility. A gene therapy for a common and severe form of retinitis pigmentosa (RP), RPGR-associated X-linked RP, botaretigene sparoparvovec (MeiraGTx Holdings plc and Janssen Pharmaceuticals), demonstrated improvements in retinal sensitivity and visual function compared with controls and had a manageable adverse event profile, according to Michel Michaelides, MD, from the UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, UK.
Nature.com

Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response

AAV-delivered CRISPR/Cas9 (AAV-CRISPR) has shown promising potentials in preclinical models to efficiently insert therapeutic gene sequences in somatic tissues. However, the AAV input doses required were prohibitively high and posed serious risk of toxicity. Here, we performed AAV-CRISPR mediated homology-independent knock-in at a new target site in mAlb 3'UTR and demonstrated that single dose of AAVs enabled long-term integration and expression of hF9 transgene in both adult and neonatal hemophilia B mice (mF9 −/−), yielding high levels of circulating human Factor IX (hFIX) and stable hemostasis restoration during entire 48-week observation period. Furthermore, we achieved hemostasis correction with a significantly lower AAV dose (2 × 109 vg/neonate and 1 × 1010 vg/adult mouse) through liver-specific gene knock-in using hyperactive hF9R338L variant. The plasma antibodies against Cas9 and AAV in the neonatal mice receiving low-dose AAV-CRISPR were negligible, which lent support to the development of AAV-CRISPR mediated somatic knock-in for treating inherited diseases.
frontlinegenomics.com

Gene therapy for neurological diseases possible with new brain-targeting viral vectors

A major challenge in the field of gene therapy is ensuring that treatments are delivered to the correct location in the body. However, some destinations, like the brain, are more difficult to reach. A family of adeno-associated viral vectors (AAV) that can enter the brain has now been developed by...
canescountry.com

Hurricanes sign Kochetkov to four-year extension

Carolina Hurricanes fans will have just a bit more to be thankful for this season as the team announced that they had signed goaltender Pyotr Kochetkov to a four-year, $2 million AAV contract on Wednesday morning. The young Russian netminder broke out for a big season with the Chicago Wolves...
RALEIGH, NC
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