COVID-19 registry finds significant increased risk of in-hospital mortality for STEMI patients compared to pre-pandemic

The latest analysis from The North American COVID-19 STEMI (NACMI) was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2022 Scientific Sessions. The findings show clinical characteristics and management strategies differ by gender, but in-hospital mortality rates remained high among both groups. The findings were simultaneously published in JSCAI.
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New clue about why Covid is deadlier for men: Estrogen may play a protective role

It's one of the pandemic's prolonged mysteries: Why have men died of Covid at higher rates than women?. Covid's fatality rate for men was 1.7 times higher, on average, than the rate for women across 38 countries, a 2020 study found. More recent research from Harvard University scientists found that although men represented 49 percent of Covid cases in the U.S., they accounted for 55 percent of Covid deaths from April 2020 through May 2021.
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Addenbrooke's Hospital breached duty of care over stroke patient

A hospital patient would have not suffered a "massive" stroke had she been given the correct clot reducing drug, a High Court judge ruled. The court found Addenbrooke's Hospital in Cambridge breached its duty of care when staff treated Phoebe Pickering. Mr Justice Ritchie said she could have had a...

Alterations of the gut microbial community structure and function with aging in the spontaneously hypertensive stroke prone rat

Gut dysbiosis, a pathological imbalance of bacteria, has been shown to contribute to the development of hypertension (HT), systemic- and neuro-inflammation, and blood"“brain barrier (BBB) disruption in spontaneously hypertensive stroke prone rats (SHRSP). However, to date individual species that contribute to HT in the SHRSP model have not been identified. One potential reason, is that nearly all studies of the SHRSP gut microbiota have analyzed samples from rats with established HT. The goal of this study was to examine the SHRSP gut microbiota before, during, and after the onset of hypertension, and in normotensive WKY control rats over the same age range. We hypothesized that we could identify key microbes involved in the development of HT by comparing WKY and SHRSP microbiota during the pre-hypertensive state and longitudinally. Systolic blood pressure (SBP) was measured by tail-cuff plethysmography and fecal microbiota analyzed by16S rRNA gene sequencing. SHRSP showed significant elevations in SBP, as compared to WKY, beginning at 8Â weeks of age (p"‰<"‰0.05 at each time point). Bacterial community structure was significantly different between WKY and SHRSP as early as 4Â weeks of age, and remained different throughout the study (p"‰="‰0.001"“0.01). At the phylum level we observed significantly reduced Firmicutes and Deferribacterota, and elevated Bacteroidota, Verrucomicrobiota, and Proteobacteria, in pre-hypertensive SHRSP, as compared to WKY. At the genus level we identified 18 bacteria whose relative abundance was significantly different in SHRSP versus WKY at the pre-hypertensive ages of 4 or 6Â weeks. In an attempt to further refine bacterial candidates that might contribute to the SHRSP phenotype, we compared the functional capacity of WKY versus SHRSP microbial communities. We identified significant differences in amino acid metabolism. Using untargeted metabolomics we found significant reductions in metabolites of the tryptophan-kynurenine pathway and increased indole metabolites in SHRSP versus WKY plasma. Overall, we provide further evidence that gut dysbiosis contributes to hypertension in the SHRSP model, and suggest for the first time the potential involvement of tryptophan metabolizing microbes.

Risk Factors for Dementia May Change With Age

FRIDAY, May 20, 2022 (HealthDay News) -- Dementia risk factors appear to shift with age, and experts say knowing that could help people make lifestyle changes to reduce their chances of developing the disease. "Dementia is a complicated disease and risk prediction scores need to be tailored to the individual,"...

SCAI issues official guidelines for the management of patent foramen ovale

The Society for Cardiovascular Angiography & Interventions (SCAI) today released official guidelines for the management of patent foramen ovale (PFO). A multidisciplinary guideline panel formulated 13 recommendations to address five PFO clinical scenarios. The document was published in the Journal of the Society for Cardiovascular Angiography & Interventions (JSCAI). The...

Nottingham stroke patient calls for more research volunteers

A retired chemist who had a stroke is calling for people to get involved in research. Dr Fred Higton, from Nottingham, became a research volunteer in 2011 after he received life-saving treatment for a stroke. He is now part of a National Institute Health and Care Research (NIHR) campaign to...