Santa Clara is a city in Santa Clara County, California. The city's population was 116,468 as of the 2010 United States Census, making it the ninth-most populous city in the San Francisco Bay Area. Located on the southern coast of San Francisco Bay immediately west of San Jose and 45 miles (72 km) southeast of San Francisco, the city was founded in 1777 with the establishment of Mission Santa Clara de As�s, the eighth of 21 California missions. The city was later incorporated in 1852. The mission, the city, and the county are all named for Saint Clare of Assisi.