Thomas Willis was a renowned physician who made breakthrough studies in the anatomy of human body in particular the brain. Born to nobility, his family had to face lot of opposition during the Civil War in Britain and their family lost a lot of ancestral property, which were annexed by the Parliament. He even served as a physician to the royal family during the reign of Charles I of England. After the war, he started his practice in the Westminster town of London and embarked on study of anatomy. His pioneering works in relation to neurophysiology were highly elaborate in comparison to prior studies undertaken. He even studied the cause and effect of various convulsive disorders like epilepsy and his findings heralded a new era in psychiatric treatment. Concentrating on metabolic diseases, he conducted an extensive study of diabetes mellitus; it was he who named the disease as mellitus. His expertise on anatomy of human brain is reflected in the paper he published on the ‘Circle of Willis’, which describes the flow of blood in the brain. The pioneering scientist continued to work till his last days and was highly regarded among his peers. Read on to know more about his life and works.