The comedians Nick Kroll and Jason Mantzoukas have been friends for nearly two decades—they met after orbiting each other in the fizzy New York comedy scene of the early two-thousands, and cemented their bond over sandwiches at an old-school diner in Manhattan. Kroll is best known as a co-creator, writer, and star of the adult animated series “Big Mouth,” in which he voices Nick Birch, a protagonist loosely based on his teen-age self, as well as a smorgasbord of tertiary characters, including a foul-mouthed ladybug, a box of tampons, and a chain-smoking Statue of Liberty. If Kroll is distinguished by his formidable vocal skills and talent for mimicry, Mantzoukas is striking for his physicality: onscreen, he nearly vibrates with pent-up energy, eyes wide and hair corkscrewing in all directions. He has carved out a niche for himself playing chaotic, borderline unsettling eccentrics like the ex-detective Adrian Pimento on “Brooklyn Nine-Nine” and the glitch-ridden Derek on “The Good Place.” (As he put it to me, and to the creators of one sitcom in which he was vying for a part, “I happen to play a great maniac.”)