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Beyond the spike: New antibody analysis predicts severe COVID-19 outcomes

Most research on immunity to the SARS-CoV-2 virus and COVID-19 vaccine development has focused on antibody responses to the spike protein and other viral surface proteins. But antibodies that recognize the virus's internal proteins could also be important for immunity and disease outcomes, according to a new study led by University of Pittsburgh, Georgia Institute of Technology and Emory University researchers.
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New COVID-19 Variants Dodge Vaccine Antibodies, New Study Reveals

Omicron's BA.4 and BA.5 subvariants "substantially" escaped antibody responses in people previously infected with COVID-19 and the fully vaccinated and boosted, new research showed. The median neutralizing antibody response against the two subvariants among 27 previously infected people was lower than omicron's original strain by a factor of 2.9, according...
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COVID vaccines are safe for people with heart disease

Scientists from The University of Hong Kong found that COVID-19 vaccination is not linked to an increased risk of heart attack or stroke in people with heart disease. The pre-existing cardiovascular disease should not prevent people from getting vaccinated against COVID-19. The research is published in Cardiovascular Research and was...
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Study finds repurposed drug inhibits enzyme related to COVID-19

With the end of the pandemic seemingly nowhere in sight, scientists are still very focused on finding new or alternative drugs to treat and stop the spread of COVID-19. In a first-of-its-kind study, researchers at the University of New Hampshire have found that using an already existing drug compound in a new way, known as drug repurposing, could be successful in blocking the activity of a key enzyme of the coronavirus, or SARS-CoV-2, which causes COVID-19.
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New insights into role of anticoagulants in patients with thrombosis after SARS-CoV-2 vaccination

A research team led by Prof. Dr. Tamam Bakchoul from the Institute for Clinical and Experimental Transfusion Medicine (IKET) at the University Hospital of Tübingen is investigating the suitability of anticoagulants in patients who develop thrombosis at unusual sites after vaccination against SARS-CoV-2. With the help of the study results, the scientists and physicians are hopeful to further explore new approaches to the treatment of this rare yet deadly condition. The study is now published in the journal Blood.
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COVID-19 can rebound after taking oral med Paxlovid

Scientists from University of California San Diego found why COVID-19 can rebound after taking oral med Paxlovid. The research is published in Clinical Infectious Diseases and was conducted by Davey M. Smith et al. Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals. However,...
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COVID-19 rebound after taking Paxlovid likely due to insufficient drug exposure

Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals. However, symptoms returned in some patients after treatment was completed, prompting the Centers for Disease Control and Prevention (CDC) to issue a health advisory on this so-called "COVID-19 rebound." In a study published June 20,...
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Study compares baricitinib to dexamethasone for COVID-19

For hospitalized patients with COVID-19 requiring supplemental oxygen, baricitinib plus remdesivir and dexamethasone plus remdesivir result in similar mechanical ventilation-free survival by day 29, but adverse events occur more frequently with dexamethasone, according to a study published online May 23 in The Lancet Respiratory Medicine. Cameron R. Wolfe, M.B.B.S., from...
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