After hitting the public markets for the first time on Friday, Upstream Bio Inc.'s share price soared in its first day of trading, while Camp4 Therapeutics Inc.'s stock finished the day relatively flat.<\p> Waltham’s Upstream Bio (Nasdaq: UPB) raised $255 million in its initial public offering this week, a 22% increase from the terms it set at the beginning of the week. The biotech sold 15 million shares, up from the 12.5 million it had previously laid out, at $17 each, the top of its range. <\p>

Delta Air Lines is adding a new direct flight from Boston to Costa Rica to its offerings.<\p> The new flight is the first time Delta will have a direct flight to the Central American country from Boston Logan International Airport, and will be the first year-round flight to the destination from Boston by any airline.<\p>

The Boston Planning and Development Agency on Thursday advanced a new Franciscan Children’s Hospital clinical building in Brighton as well as a master plan for Dana-Farber Cancer Institute’s proposed 300-bed hospital in Longwood.<\p> The board also approved Rhino Capital Advisors LLC’s proposed conversion of an empty office building into a hotel in Bulfinch Triangle and residential projects totaling 320 units in Brighton and Roxbury.<\p>

Female leaders in the Boston area’s life sciences industry talked about their leadership styles, their career paths and the role that mentorship can play in a male-dominated industry at a Boston Business Journal event Thursday.<\p> The BBJ’s Women Who Lead in Life Sciences panelists often took circuitous routes to their leadership position roles at area companies, and they said they’ve often made a point of seeking out mentors — and being one to others, especially when there are fewer women in the field as superiors or peers.<\p>

Some of the state's health policy commissioners have concerns about the upcoming sale of Steward Health Care's physician group to another private equity owner—but acknowledged that there are few alternatives.<\p> The sale, to relatively young private equity body called Rural Healthcare Group, a Nashville-based healthcare group owned by private equity firm Kinderhook Industries LLC is likely to close on October 30th. The acquisition is set to cost RHG $245 million. <\p>

The strikes by hotel workers at two Hilton hotel properties in Boston have entered their sixth day, and are poised to continue into the holiday weekend.<\p> Almost 600 workers at the Hilton Boston Park Plaza in Back Bay and the Hilton Boston Logan Airport began what they called an indefinite strike on Sunday, Oct. 6. Picketers have been outside the hotels since. <\p>

It can be difficult to pull the trigger on a big purchase—so for the past few years, retailers have turned to AI-generated questionnaires to guide customers to the specific appliance that best suits their needs.<\p> The company behind the software many of those retailers use is Boston-based Zoovu. Now, the company is expanding its conversational sales assistant through a new partnership with Microsoft Azure. <\p>

Overall, the median price for a single-family home in Greater Boston keeps going up. But the same can’t be said for every town in the region.<\p> Of the 64 communities in the Greater Boston Association of Realtors’ jurisdiction, nearly a quarter saw a year-over-year decline in the median sale price for single-family homes through August, according to data from the Massachusetts Association of Realtors.<\p>

Massachusetts colleges and universities facilitate students' professional and personal development and contribute to the state’s economy by building our skilled workforce. Internships are important to these outcomes and give an edge to students and employers. When businesses and higher education work together to create high-quality internship experiences, students, employers, and the economy benefit. <\p> A college’s curriculum provides students with critical thinking and hard skills needed for career building. Equally important are being job-ready, workplace-appropriate soft skills, and knowing what career you want – all of which come with the experiential learning of paid and unpaid internships. While internship programs vary among colleges, the common denominators of success are happy graduates in jobs they love, and employers pleased to hire their interns.<\p>

Architectural firms are increasingly designing buildings in the Boston area with an eye toward how they can leave as light of a footprint as possible on the environment.<\p> In some cases, environmentally friendly features come at the urging of a client. But in others, they meet strict building-code requirements established in places like Boston and Cambridge.<\p>

Over nearly three decades, John Toomey has worked his way up the ranks to lead the state’s largest independent investment advisory firm. <\p> Toomey joined global private market asset manager HarbourVest in 1997 as a member of the firm’s direct investment team. He was guided by those with years of experience in the industry. And now, with decades of experience under his belt, it’s the ability to help the next generation that inspires him as he assumes the role of sole CEO for HarbourVest.<\p>

Good morning, Boston. Here are the five things you need to know in local business news to start your busy Friday, plus takeaways from a lunch with the CEO of McDonald's. <\p> Greg Ryan reports that BXP Inc. (formerly known as Boston Properties) is proposing to redevelop a Kendall Square building into a taller lab tower, while shrinking an already-approved lab project on Binney Street.<\p>

Cambridge’s Camp4 Therapeutics Inc. and Waltham’s Upstream Bio Inc. will both make their debuts on the public markets Friday.<\p> Upstream raised $255 million, up 22% from the terms it set earlier this week, selling 15 million shares (more than the 12.5 million it said previously) at $17 each, the top of its range. <\p>

The CEO of fast-food giant McDonald’s Corp. spoke at a Boston business luncheon Thursday, and the menu for discussion included mobile technology, customer tastes and values, and corporate culture.<\p> Boston-born Chris Kempczinski became CEO and chairman of McDonald’s (NYSE: MCD) in November 2019, leading the global franchise company through the Covid pandemic.<\p>

The CEO of fast-food giant McDonald’s Corp. spoke at a Boston business luncheon Thursday, and the menu for discussion included mobile technology, customer tastes and values, and corporate culture. Boston-born Chris Kempczinski became CEO and chairman of McDonald’s (NYSE: MCD) in November 2019, leading the global franchise company through...

Alexandria Eberhardt will be the next executive director of the Massachusetts LGBT Chamber of Commerce.<\p> Eberhardt, who has led the Greater Haverhill Chamber of Commerce since March 2022, will begin in the role next week, according to the announcement from the organization.<\p>

Alexandria Eberhardt will be the next executive director of the Massachusetts LGBT Chamber of Commerce. Eberhardt, who has led the Greater Haverhill Chamber of Commerce since March 2022, will begin in the role next week, according to the announcement from the organization. "This opportunity aligns perfectly with my passion for...

BXP Inc. is proposing to redevelop a Kendall Square building into a taller lab tower and to shrink the size of an already-approved lab project on Binney Street.<\p> The impetus for the change in plans is a Thermo Fisher Scientific Inc. subsidiary’s intention to stay in the existing facility now at the Binney site through at least 2029, a sublease that has been the subject of litigation.<\p>

A C-level executive at one of the state's largest public companies by revenue is on her way out. <\p> Anelise Sacks, chief customer officer at Analog Devices Inc., is slated to leave the Wilmington-based semiconductor maker (Nasdaq: ADI) at the end of March next year, according to an Oct. 10 public filing with the U.S. Securities and Exchange Commission. <\p>

A C-level executive at one of the state's largest public companies by revenue is on her way out. Anelise Sacks, chief customer officer at Analog Devices Inc., is slated to leave the Wilmington-based semiconductor maker (Nasdaq: ADI) at the end of March next year, according to an Oct. 10 public filing with the U.S. Securities and Exchange Commission.